Reelin Glycoprotein (eBook)
XXIII, 443 Seiten
Springer New York (Verlag)
978-0-387-76761-1 (ISBN)
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.
The Reelin Gene and Its Functions in Brain Development
Cheng-Chiu Huang, MS
Gabriella D’Arcangelo, PhD*
Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An Overview
Dr. Hans H. Bock*
Prof. Dr. Joachim Herz
Chemistry of Reelin
Yves Jossin, PhD*
The C-terminal region of Reelin: structure and function
Mitsuharu Hattori, PhD*
Crystal Structure of Reelin Repeats
Junichi Takagi, PhD*
Comparative Anatomy and Evolutionary Roles of Reelin
Gundela Meyer, MD, PhD*
Reelin / Dab1 Signaling in the Developing Cerebral Cortex
Eric C. Olson, PhD*
Christopher A. Walsh, MD, PhD
Ultrastructural Localization of Reelin
Rosalinda C. Roberts, PhD*
Emma Perez-Costas, PhD
Reelin and Cyclin-Dependent Kinase 5
Toshio Ohshima, MD, PhD*
Reelin and the Cerebellum
Robert F. Hevner, MD, PhD*
Reelin and Radial Glial Cells
Eckart Forster, PhD
Shanting Zhao, MD
Michael Frotscher, MD*
Reelin and Cognition
Shenfeng Qiu, PhD
Edwin John Weeber, PhD*
Protein Kinases and Signaling Pathways that are Activated by Reelin
Jonathan A. Cooper, PhD*
Nathaniel S. Allen, BS
Libing Feng, PhD
The Relationship of Oxytocin and Reelin in the Brain
George D. Pappas, PhD*
C. Sue Carter, PhD
Reelin and Thyroid Hormone
Manuel Alvarez-Dolado, PhD*
A Tale of Two Genes: Reelin and BDNF
Thomas Ringstedt, PhD*
Reelin, Liver, and Lymphatics
BrigitteSamama, PhD*
Nelly Boehm, MD, PhD
Reelin and Cajal-Retzius Cells
Jean-Marc Mienville, PhD*
Reelin and Odontogenesis
Francoise Bleicher*
Henry Magloire
Marie-Lise Couble
Jean-Christophe Maurin
Homozygous and Heterozygous Reeler Mouse Mutants
Patricia Tueting, PhD*
Graziano Pinna, PhD
Erminio Costa, MD
Reelin and Lissencephaly
Elena Parrini, PhD
Renzo Guerrini, MD*
The Role of Reelin in Etiology and Treatment of Psychiatric Disorders
S. Hossein Fatemi, MD, PhD*
Teri J. Reutiman, BA
Timothy D. Folsom, MS
Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia
Erminio Costa, MD*
Ying Chen, PhD
Erbo Dong PhD
Dennis R. Grayson, PhD
Alessandro Guidotti, MD
Marin Veldic, MD
Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder
Hamid Mostafavi Abdolmaleky, MD*
Cassandra L. Smith PhD
Jin-Rong Zhou, PhD
Sam Thiagalingam, PhD
Reelin Gene Polymorphisms in Autistic Disorder
Carla Lintas PhD
Antonio Maria Persico, MD*
Alzheimer’s and Reelin
Arancha Botella-Lopez, BS
Javier Saez-Valero, PhD*
Reelin and Stroke
Kunlin Jin, MD, PhD*
Reelin and Pancreatic Cancer
Kimberly Walter, BS
Michael Goggins, MD*
Erscheint lt. Verlag | 4.6.2008 |
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Zusatzinfo | XXIII, 443 p. |
Verlagsort | New York |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Naturwissenschaften ► Biologie ► Zoologie | |
Schlagworte | Alzheimer • Alzheimer's disease • anatomy • Autism • brain • cerebral cortex • Cognition • Cortex • Oxytocin • Protein • receptor • Schizophrenia • stroke |
ISBN-10 | 0-387-76761-4 / 0387767614 |
ISBN-13 | 978-0-387-76761-1 / 9780387767611 |
Haben Sie eine Frage zum Produkt? |
Größe: 9,5 MB
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