Angiogenesis (eBook)

An Integrative Approach from Science to Medicine

William D. Figg, Judah Folkman (Herausgeber)

eBook Download: PDF

2008 | 2008
XIX, 601 Seiten
Springer US (Verlag)
978-0-387-71518-6 (ISBN)

Infos

Dr. Judah Folkman is considered the 'father of angiogenesis.' Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

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Dr. Judah Folkman, "e;father of angiogenesis"e;, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases.This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters.Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.

Inhalt

History of Angiogenesis.- Angiogenesis and Vascular Remodeling: Biology and Architecture of the Vasculature.- Endothelial Cell Activation.- Pericytes, the Mural Cells of the Microvascular System.- Matrix Metalloproteinases and Their Endogenous Inhibitors.- Integrins in Angiogenesis.- Fibroblast Growth Factor-2.- Vascular Permeability Factor/Vascular Endothelial Growth Factor.- Platelet-derived Growth Factor.- Angiopoietins and Tie Receptors.- Basement Membrane-derived Inhibitors of Angiogenesis.- Endostatin and Angiostatin.- Thrombospondins.- Overview of Angiogenesis during Tumor Growth.- Hypoxic Regulation of Angiogenesis by HIF-1.- Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2.- Nitric Oxide in Tumor Angiogenesis.- VEGF Signal Transduction in Angiogenesis.- Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis.- Immune Cells and Inflammatory Mediators as Regulators of Angiogenesis.- Contribution of Endothelial Progenitor Cells to the Angiogenic Process.- The Cancer Stem Cell Model.- Targeting the Tumor Microenvironment (Stroma).- Normalization of Tumor Vasculature and Microenvironment.- Targeted Drug Delivery to the Tumor Neovasculature.- Models for Angiogenesis.- Surrogates for Clinical Development.- Imaging of Angiogenesis.- Tumor Endothelial Markers.- Overview and Clinical Applications of VEGF-A.- Protein Tyrosine Kinase as Antiangiogenic Agents.- Therapeutic Strategies that Target the HIF System.- The Clinical Utility of Bevacizumab.- Development of Thalidomide and its IMiD Derivatives.- TNP-470: The Resurrection of One of the First Angiogenesis Inhibitors.- Clinical Development of VEGF Trap.- Recent Advances in Angiogenesis Drug Development.- Combination of Angiogenic Therapy with other Anticancer Therapies.- Immunotherapy of Angiogenesis with DNA Vaccines.- Challenges of Antiangiogenic Therapy of Tumors.- Pharmacogenetics of Antiangiogenic Therapy.- Angiogenesis in the Central Nervous System.-Lymphatic Vascular System and Lymphangiogenesis.- Ocular Neovascularization.- Angiogenesis and Pathology in the Oral Cavity.- Revascularization of Wound: The Oxygen-Hypoxia Paradox.- Journeys in Coronary Angiogenesis.- Perspectives on the Future of Angiogenesis Research.

Produkt-Details

• Erscheint lt. Verlag: 24.5.2008
• Zusatzinfo: XIX, 601 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: angiogenesis • Cell Biology • Endothelium • Imaging • Regulation • Surgery • tumor growth
• ISBN-10: 0-387-71518-5 / 0387715185
• ISBN-13: 978-0-387-71518-6 / 9780387715186