Mechanisms of Angiogenesis (eBook)

Matthias Clauss, Georg Breier (Herausgeber)

eBook Download: PDF

2006 | 2005
XIV, 324 Seiten
Springer Basel (Verlag)
978-3-7643-7311-5 (ISBN)

Infos

Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Inhalt

Contents 5
List of contributors 7
Preface 10
Basic principles in physiological and pathophysiological angiogenesis 14
How do endothelial cells orientate? 15
New insights into intussusceptive angiogenesis 28
Angiogenesis in the female reproductive system 45
Arterialization, coronariogenesis and arteriogenesis 63
Sprouting angiogenesis versus co-option in tumor angiogenesis 74
Hormones and the neovascularization process: role of angiotensin II 86
Can tumor angiogenesis be inhibited without resistance? 103
Cellular and physical mechanisms of blood vessel growth 121
Role of pericytes in vascular morphogenesis 122
Role of monocytes and macrophages in angiogenesis 133
Bone marrow-derived endothelial progenitor cells for neovascular formation 153
Can angiogenesis be exercised? 161
Angiogenesis - a self-adapting principle in hypoxia 168
Cellular mechanisms of arteriogenesis 186
Balancing luminal size and smooth muscle proliferation Ò a key control point in atherosclerosis and arteriogenesis 197
Molecular mechanisms of angiogenesis 210
The role of VEGF in the regulation of physiological and pathological angiogenesis 211
The anti-inflammatory actions of angiopoietin-1 234
The hemostatic system in angiogenesis 247
Signal transduction in angiogenesis 267
Index 301

Produkt-Details

• Erscheint lt. Verlag: 17.1.2006
• Reihe/Serie: Experientia Supplementum
• Reihe/Serie: Experientia Supplementum
• Zusatzinfo: XIV, 324 p.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: angiogenesis • Angiotensin II • atherosclerosis • Blood vessel • Bone • Cells • Endothelium • heart • hormones • Macrophages • Morphogenesis • Regulation • smooth muscle • Tumor
• ISBN-10: 3-7643-7311-3 / 3764373113
• ISBN-13: 978-3-7643-7311-5 / 9783764373115