Cancer: Cell Structures, Carcinogens and Genomic Instability (eBook)

Leon P. Bignold (Herausgeber)

eBook Download: PDF

2006 | 2006
XI, 376 Seiten
Springer Basel (Verlag)
978-3-7643-7378-8 (ISBN)

Infos

This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic instability. After many years of teaching the theories of c- cer in undergraduate medical school courses, it seemed to me that the variably chaotic histopathologic features of tumours parallel in some way, the variably unstable genomes of tumour cells, which were being discovered in the 1990s. Thus the title of the volume has come to include morphology, carcinogenesis and genetic instability. The invitation came while I was working with Herrn Dr. med. Hubertus Jersmann (MD Düsseldorf, PhD, now Senior Lecturer in Medicine of the University of Adelaide) and Professor Brian Coghlan (Emeritus Professor of German, the University of Adelaide), on the work of the nineteenth century cancer pathologists, especially David Paul von Hansemann (1858-1920). With the delivery of the manuscripts from the authors of the chapters, it became obvious that a background chapter for the volume could include some of the material which we had 'uncovered' together. Because of this, chapter 1 is authored by the three of us, and the 'new' material figures prominently.

Inhalt

Contents 5
List of Contributors 7
Preface 10
Cancer morphology, carcinogenesis and genetic instability: a background 11
Abnormalities of chromatin in tumor cells 35
Aneuploidy, stem cells and cancer 58
The mode of action of organic carcinogens on cellular structures 74
Metal ions and carcinogenesis 105
Actions of ultraviolet light on cellular structures 139
Actions of radiation on living cells in the “postbystander” era 166
Viral carcinogenesis and genomic instability 185
Abnormalities of cell structures in tumors: apoptosis in tumors 206
Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications 227
Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview 273
Effects of ionizing radiation on cellular structures, induced instability and carcinogenesis 297
Genetic instability in human tumors 306
Molecular mechanisms of human carcinogenesis 324
Mechanisms of abnormal gene expression in tumor cells 353
Index 364

Produkt-Details

• Erscheint lt. Verlag: 27.1.2006
• Reihe/Serie: Experientia Supplementum
• Reihe/Serie: Experientia Supplementum
• Zusatzinfo: XI, 376 p.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: angiogenesis • animals • Apoptosis • Behavior • Cancer • Cancer Research • carcinogen • Carcinogenesis • Cell • gene expression • genes • Genome • pathogenesis • prevention • Regulation • Tumor
• ISBN-10: 3-7643-7378-4 / 3764373784
• ISBN-13: 978-3-7643-7378-8 / 9783764373788