Glutamate Receptors in Peripheral Tissue (eBook)

Excitatory Transmission Outside the CNS

Santokh Gill, Olga Pulido (Herausgeber)

eBook Download: PDF

2007 | 2005
420 Seiten
Springer US (Verlag)
978-0-306-48644-9 (ISBN)

Infos

Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections- Part I is on general concepts and concentrates on the distribution and cell-specific localiza­ tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.

Inhalt

Preface 6
Contents 7
Part I General Concepts 14
Glutamate Receptors in Peripheral Tissues: Distribution and Implications for Toxicology 15
Glutamate Receptor Pharmacology: Lessons Learned from the Last Decade of Stroke Trials 39
Expression of Non-Organelle Glutamate Transporters to Support Peripheral Tissue Function 58
Anticancer Effects of Glutamate Antagonists 87
Glutamate Receptors and their Role in Acute and Inflammatory Pain 96
Part II Specific Target Tissues, Organs, and Systems 106
The Vertebrate Retina 107
Glutamate Receptors in Taste Receptor Cells 137
Glutamate Receptors in Endocrine Tissues 154
Adrenal Glutamate Receptors: A Role in Stress and Drug Addiction? 176
Glutamate Receptors in the Stomach and their Implications 186
Glutamate Toxicity in Lung and Airway Disease 198
Glutamate: Teaching Old Bones New Tricks — Implications for Skeletal Biology 204
Expression and Function of Metabotropic Glutamate Receptors in Liver 217
Neuroexcitatory Signaling in Immune Tissues 225
Platelet Glutamate Receptors as a Window into Psychiatric Disorders 239
Part III Non- Mammalian Organisms 248
Analysis of Glutamate Receptor Genes in Plants: Progress and Prospects 249
Index 262

Produkt-Details

• Erscheint lt. Verlag: 31.1.2007
• Zusatzinfo: 420 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: Biology • brain • Calcium • Cancer • Molecular Biology • neurons • Time
• ISBN-10: 0-306-48644-X / 030648644X
• ISBN-13: 978-0-306-48644-9 / 9780306486449