The GABA Receptors (eBook)

Salvatore J. Enna, Hanns Möhler (Herausgeber)

eBook Download: PDF

2007 | 3rd ed. 2007
X, 325 Seiten
Humana Press (Verlag)
978-1-59745-465-0 (ISBN)

Infos

The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

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This volume is the third edition of a monograph series that was first published in 1983. The demand for this work is a testament to the impact of studies on -aminobutyric acid (GABA) receptors on the basic understanding of synaptic transmission and on defining the clinical importance of the neurotransmitter system. Chronicled in The GABA Receptors, Third Edition, are the advances made in understanding the molecular and pharmacological properties of GABA A and GABA receptors since the topic was last reviewed in 1996. Particular B emphasis is placed on describing the assembly, structure, and function of GABA B sites, the first heterodimeric G protein-coupled receptors identified in vivo. In addition, there are reports dealing with the subunit composition, trafficking, and pharmacological selectivity of GABA receptors. Aside from providing A insights into the fundamental properties of ligand-gated ion channels and second messenger systems, the findings detailed in this work point the way for developing novel therapeutics capable of more selectively manipulating these transmitter sites.

Inhalt

Preface 6
Contents 7
Contributors 9
1 The GABA Receptors 11
2 Functional Relevance of GABAA-Receptor Subtypes 32
3 Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins 49
4 Subunit Composition and Structure of GABAA-Receptor Subtypes 76
5 Differential Activation of GABAA-Receptor Subtypes 94
6 GABAA-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures 118
7 Abuse and Dependence Liability of GABAA-Receptor Modulators 150
8 Mechanisms of GABAA and GABAB Receptor Gene Regulation and Cell Surface Expression 176
9 Chemistry of GABAB Modulators 246
10 The Unusual Functioning of the GABAB-Receptor Heterodimer 259
11 Characteristics of GABAB Receptor Mutant Mice 278
12 GABAB Receptor as a Potential Therapeutic Target 293
Index 317

Produkt-Details

• Erscheint lt. Verlag: 17.11.2007
• Reihe/Serie: The Receptors
• Reihe/Serie: The Receptors
• Zusatzinfo: X, 325 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• Schlagworte: Activation • Autism spectrum disorder • Endoplasmatisches Reticulum • Epilepsie • gene expression • genes • Regulation
• ISBN-10: 1-59745-465-6 / 1597454656
• ISBN-13: 978-1-59745-465-0 / 9781597454650