Ubiquitin Proteasome System in the Central Nervous System
Nova Science Publishers Inc (Verlag)
978-1-60021-749-4 (ISBN)
The book focuses on the role of ubiquitin proteasome system (UPS) in central nervous system. Proteasomes are large multicatalytic proteinase complexes that are found in the cytosol and in the nucleus of eukaryotic cells with a central role in cellular protein turnover. The UPS has a central role in the selective degradation of intracellular proteins. In addition to serving as a means to rapidly eliminate short-lived regulatory proteins involved in cell cycle, cell growth, and differentiation, in periods of stress rapid elimination of denatured, misfolded and damaged proteins by the proteasome becomes a critical determinant of cell fate. These aspects are analysed in central nervous system physiology and pathology.
Preface; Focusing on the Ubiquitin Proteasome System in Nervous System; Intracellular Protein Degradation: From a Vague Idea thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting; Ubiquitin and Ubiquitination: An Overview of the Ubiquitin-Proteasome System for Protein Degradation; Diversity and Cellular Functions of Deubiquitinating Enzymes; Ubiquitin Domain Proteins Functional Variations of a Common Structure; Structure and Function of The 20S Proteasomes; Structure and Function of the 26S Proteasomes; Assays with Natural Substrates: Novel Tools to address the Complexity of Protein Degradation by 26S Proteasomes; Proteasome Activators, Inhibitors and Associated Proteins; The Molecular Chaperones in the Ubiquitin-Proteasome System; Intracelluar Localisation of Proteasomes; Aggresome Formation: A Failure of the Ubiquitin-Proteasome System; Endoplasmic Reticulum (ER) Stress, ER-Associated Degradation and Unfolded Protein Response; Threoretical Models for Proteasome Function: Predictive Methods to Understand Ubiquitin Protein System in Neurodegenerative Diseases; The Ubiguitin-Proteasome System and The Development of The Nervous System; General Aspects of Ubiquitin Proteasome System in The Mature Central Nervous System; Ubiquitin-Proteasome System in The Peripheral Nervous System: Functional and Morphological Aspects; Dynamic Regulation of Synpatic Regulation of Synaptic Plasticity by The Ubiquitin Proteasome System; The Role of The Ubiquitin Proteasome System in Modifying Celluar Stress Responses; The Homeostatic Control of Glucocorticoid Receptor in The Central Nervous System by The Ubiquitin-Proteasome System; Role of The Ubiquitin- and Proteasome System in Neuronal Apoptosis; Molecular Chaperones and The Ubiquitin Proteasome System in Aging; Impairment of The Ubiquitin-Proteasome System: A Common Pathogenic Mechanism in Neurodegenerative Disorders; Neuroprotective and Pro-Apoptotic Responses of Ubiquitin Proteasome System; Ubiquitin Proteasome System Pathway in Dopaminergic Neurodegeneration; The Ubiquitin-Proteasome System in Axon Degeneration; The Ubiquitin Proteasome System in Pain Transmission and Neuropathic Pain; The Ubiquitin Proteasome System in Neurological Disorders: From Conformational Diseases to Proteasomepathies; Mechanisms involved in The Aggregation of Ubiquitinated Proteins in Neurodegenerative Disorders; The Regulation of TAU Protein Proteolysis by The Ubiquitin Proteasome System in Neurodegenerative Foldopathies; Ubiquitin-Dependent Proteolysis in Parkinson's Disease; The Ubiquitin-Proteasome System in Huntington's Disease and other Polyglutamine Diseases; The Role of The Ubiquitin Proteasome System in The Pathogenesis of Prion Diseases; Role of The Ubiquitin Proteasome System in Antigen Presentation, Autoimmune Disorders and Inflammation in The Central Nervous System; The Functional Role of Proteasome Antibodies in Neurological Disorders; The Ubiquitin Proteasome System in The Pathobiology of Human Gliomas; The Ubiquitin Proteasome System in The Pathobiology of Human Pituitary Tumours; The Role of The Ubiquitin-Proteasome System in Epilepsy and Seizure Susceptibility; The Ubiquitin Proteasome System in Cerebral Ischemia; Pharmacology of The Ubiquitin Proteasome System: Proteasome Inhibitors and Modulators; Preclinical Data on The Use of Proteasome Inhibitors: A New Approach to Treatment of Nervous System Diseases; Clinical Experience of Proteasome Inhibitors in Central Nervous System Diseases; Clinical Application of Proteasome Inhibitor Bortezomib: Characterisation of Neurotoxicity; Index.
| Zusatzinfo | Illustrations |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 260 x 180 mm |
| Gewicht | 2658 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| ISBN-10 | 1-60021-749-4 / 1600217494 |
| ISBN-13 | 978-1-60021-749-4 / 9781600217494 |
| Zustand | Neuware |
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