Human Stefins & Cystatins

Eva Zerovnik, Natasa Kopitar Jerala (Herausgeber)

Buch | Hardcover

201 Seiten

2006
Nova Science Publishers Inc (Verlag)
978-1-60021-233-8 (ISBN)

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Brings information on developments in studies of human stefins and cystatins, proteins with the function of cystein proteases (cathepsins) inhibition. This work includes chapters that start at the level of genes, and ends with describing different disease states where stefins or cystatins are involved, from Alzheimer's disease, epilepsy to cancer.

This book brings up-to-date information on developments in studies of human stefins and cystatins, proteins with the function of cystein proteases (cathepsins) inhibition. The chapters start at the level of genes, go on with protein structure and function (proposal of alternative function), protein stability and folding, to mis-folding and mis-function. The book ends with chapters describing different disease states where stefins or cystatins are involved, from Alzheimer's disease, epilepsy to cancer.

Preface; Human cystatins -- Similarities, diversity and classification; Structural and protease inhibitory features of cystatins; Alternative functions for cystatin B implicated by its interaction with proteins other than proteases; Conclusions on the mechanism of protein folding from stefins and cystatins studies; Cystatin C domain-swapping and amyloid angiopathy: a general mechanism for the formation of amyloid fibrils; The mechanism of amyloid-fibrillation -- stefin B as a good model protein; Cystatin C role in Alzheimer disease: from neurodegeneration to neuroregeneration; Cystatins in the cells of the immune system -- a current; Stefin B (cystatin B) as the gene whose defect causes EPM1 syndrome; Role of cystatins and stefins in cancer; Cystatin C, a potential marker in various pathophysiological conditions; Index.

Erscheint lt. Verlag	2.6.2006
Zusatzinfo	Illustrations
Verlagsort	New York
Sprache	englisch
Maße	260 x 180 mm
Gewicht	628 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
ISBN-10	1-60021-233-6 / 1600212336
ISBN-13	978-1-60021-233-8 / 9781600212338
Zustand	Neuware