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Proteomics of Human Body Fluids

Principles, Methods, and Applications

Visith Thongboonkerd (Herausgeber)

Buch | Hardcover

533 Seiten

2007
Humana Press Inc. (Verlag)
978-1-58829-657-3 (ISBN)

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Rapid growth of the “proteomics” field during the past twelve years has c- tributed to significant advances in science. To date, proteomic technologies have been widely applied to examining various kinds of biological materials. Clinical proteomics is the concept of using proteomic techniques to evaluate the proteomes in clinical samples for biomarker discovery and for better understa- ing of normal physiology and pathogenic mechanisms of human diseases. Tra- lating the proteomic information to clinical practice may lead to the ultimate goals of earlier diagnosis, improved therapeutic outcome and successful prev- tion of diseases. Human body fluids are produced, secreted, and/or excreted from various tissues or organs. Major compositions of body fluids are water, organic s- stances and inorganic compounds. These compositions vary in each body fluid, making one’s function different from the others. Analyses of protein com- nents in individual fluids would increase current knowledge on the biology and physiology of various organ systems, and on the pathophysiology of diseases, which cause alterations in protein production, secretion, and/or excretion from the affected tissues or organs into the body fluids. Additionally, human body fluids are the main targets and valuable sources for biomarker discovery. As the high-throughput capability and applicability of proteomics for analyzing proteins in the body fluids have been already proven, these desires are most likely achievable by using proteomic technologies.

Principles of Proteomics Applied to Human Body Fluids.- Proteomic Strategies for Analyzing Body Fluids.- Sample Preparation of Body Fluids for Proteomics Analysis.- Multiplexed Immunoassays for Protein Profiling in Human Body Fluids.- Deciphering the Hieroglyphics of Functional Proteomics Using Small Molecule Probes.- Modification-Specific Proteomic Analysis of Glycoproteins in Human Body Fluids by Mass Spectrometry.- Plasma Proteome Database.- 2D PAGE Databases for Proteins in Human Body Fluids.- Bioinformatics and Experimental Design for Biomarker Discovery.- Integrative Omics, Pharmacoproteomics, and Human Body Fluids.- Proteomic Analysis of Specific Types of Human Body Fluids.- The Human Plasma and Serum Proteome.- Proteomics of Human Urine.- Proteomics of Human Cerebrospinal Fluid.- Proteomics of Pleural Effusion.- Proteomics of Bronchoalveolar Lavage Fluid and Sputum.- Proteomics of Sinusitis Nasal Lavage Fluid.- Proteomics of Human Saliva.- Proteomics of Human Pancreatic Juice.- Proteomics of Human Bile.- Proteomics of Amniotic Fluid.- Proteomics of Human Milk.- Proteomics of Nipple Aspirate Fluid in Nonlactating Women.- Proteomics of Seminal Fluid.- Proteomics of Vitreous Fluid.- Proteomics of Human Dialysate and Ultrafiltrate Fluids Yielded by Renal Replacement Therapy.

Zusatzinfo	7 Illustrations, color; 96 Illustrations, black and white; XIII, 533 p. 103 illus., 7 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-58829-657-1 / 1588296571
ISBN-13	978-1-58829-657-3 / 9781588296573
Zustand	Neuware