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Sphingolipid Metabolism and Metabolic Disease -

Sphingolipid Metabolism and Metabolic Disease (eBook)

Xian-Cheng Jiang (Herausgeber)

eBook Download: PDF
2022 | 1st ed. 2022
VIII, 213 Seiten
Springer Nature Singapore (Verlag)
978-981-19-0394-6 (ISBN)
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This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.

Dr. Xian-Cheng Jiang (PhD) is a Distinguished Professor at the State University of New York (SUNY). He is working at the Department of Cell Biology, SUNY Downstate Health Sciences University. His research focuses on lipid metabolism and metabolic diseases, such as atherosclerosis, metabolic syndrome, obesity and liver steatosis, particularly how sphingolipid metabolism influences plasma lipoprotein metabolism, cell membrane lipid composition and function, and the development of metabolic diseases.
This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
Erscheint lt. Verlag 3.5.2022
Reihe/Serie Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology
Zusatzinfo VIII, 213 p. 1 illus.
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Innere Medizin
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Schlagworte Lipoprotein-sphingolipid • Rare diseases in glycosphingolipid metabolism • Sphingolipid biochemistry • Sphingolipid biosynthesis • Sphingolipid metabolism and cancer • Sphingolipid metabolism and lung diseases • Sphingolipid metabolism related drug development • Sphingolipid-related diseases • Sphingomyelin biosynthesis and metabolic diseases
ISBN-10 981-19-0394-8 / 9811903948
ISBN-13 978-981-19-0394-6 / 9789811903946
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