The Annotated Hodgkin and Huxley (eBook)

A Reader's Guide

Indira M. Raman, David L. Ferster (Autoren)

eBook Download: PDF

2022
328 Seiten
Princeton University Press (Verlag)
978-0-691-22065-9 (ISBN)

Infos

The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley's rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing.This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge-and an unparalleled approach to research-accessible to a new generation of readers.Reproduces the original articles paired with extensive annotations on facing pagesReplots figures with modern conventions of data displayExplains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiologySummarizes the history of electrophysiology leading to Hodgkin and Huxley's workIncludes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods

Produkt-Details

• Erscheint lt. Verlag: 11.1.2022
• Zusatzinfo: 89 b/w illus.
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Schlagworte: absolute magnitude • Action potential • Activation • Afterhyperpolarization • Amino acid • Ampere • Amplifier • Amplitude • And/or • Andrew Huxley • Annotation • Anode • Appellation • Approximation • aqueous solution • Atom • Auditor • Availability • axon • Axoplasm • Boiling • Buffer amplifier • calcification • Calculation • capacitance • capacitor • Capillary • Cathode • cell membrane • Chloride • choline • coefficient • Conformational change • Consultant • Coulomb • crystallization • culmination • David Colander • deindustrialization • Democritus • depolarization • diagram • differential equation • Elaboration • electrode • Enneads • Epineurium • Epistemology • Eqn • Equation • estimation • ETIM (standard) • Euclid's Optics • Euler Method • Explanation • Exponential decay • exponentiation • Extrapolation • Farad • Formal fallacy • Galvanometer • Gene • General order • George Kateb • Georg Ohm • hepatocyte • Hodgkin–Huxley model • Homarus • Hyperkalemia • Hyperpolarization (biology) • Hyperpolarization (physics) • inductor • inference • ingredient • input impedance • Input/Output • Inspection • Instance (computer science) • internment • Isa Alptekin • Joseph Barcroft • Joseph Erlanger • Joule • Kinase • Linear Approximation • Map–territory relation • Measurement • Meccano • membrane potential • Myanmar • Na+/K+-ATPase • nernst equation • Neurophysiology • Neutron • Numerical Integration • Observation • Ohm • Ohm's law • Order of magnitude • Paul Ormerod • Perineurium • Plotinus • Potassium • potassium channel • potentiometer • Probability • Projectile • Protoplasm • Purkinje fibers • Quantity • reagent • red blood cell • Refractory period (physiology) • Relative Permeability • repolarization • Reversal potential • Runge–Kutta methods • RX (rocket family) • Schematic • Schwann cell • sciatic nerve • Sense • Sensor • shellac • Simultaneous Equations • Sine Wave • Single-photon emission computed tomography • sodium • Solution • Sophist • subtraction • Subunit (format) • sucrose • Summation • Synapsis • Terminology • Tetanus • Tetramer • tetrodotoxin • Theory of Forms • The Physiological Society • Thomas Henry Huxley • Transition state • treatise • Uyghurs • V+ • V curve • Volt • Voltage Clamp • Walther Nernst • Wheatstone Bridge
• ISBN-10: 0-691-22065-4 / 0691220654
• ISBN-13: 978-0-691-22065-9 / 9780691220659