Diabetes and Cardiovascular Disease

Integrating Science and Clinical Medicine

Steven P. Marso, David M. Stern (Herausgeber)

Buch | Hardcover

480 Seiten

2003
Lippincott Williams and Wilkins (Verlag)
978-0-7817-4053-1 (ISBN)

Infos

Reviews the findings and concepts on the vascular biology of diabetes mellitus, the clinical vascular manifestations of diabetes, and the therapeutic options available for diabetic patients with vascular disease. This book includes summaries of clinical trials to provide an evidence-based approach to treatment.

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This text thoroughly reviews the latest findings and concepts on the vascular biology of diabetes mellitus, the clinical vascular manifestations of diabetes, and the therapeutic options available for diabetic patients with vascular disease. The first section provides an in-depth understanding of fundamental principles and recent discoveries regarding diabetes mellitus and vascular biology. The second, clinically oriented section includes chapters on the economic implications of diabetes mellitus, risk profiling patients with diabetes, optimizing adjunctive therapies, and treatment strategies for diabetic patients with coronary and peripheral artery disease. Summaries of important clinical trials are included to provide an evidence-based approach to treatment.

Inhalt

Part I Vascular Biology

Structure and Function of the Vessel Wall, 3
Mario B. Marrero and David M. Stern


Antioxidants, Oxidative Stress, and Inflammation in Diabetes, 19
Sridevi Devaraj, Sonia Vega-López, and Ishwarlal Jialal


Role of Protein Kinase C Isoforms in Diabetic Vascular Dysfunction, 37
Zhiheng He, Ronald C.W. Ma, and George L. King


Aldose Reductase and Vascular Stress, 55
Ravichandran Ramasamy and Peter J Oates


Peroxisome Proliferator-Activated Receptors and Diabetic Vasculature, 75
Peter J. Little, Duncan J. Topliss, Sunder Mudalier, and Ronald E. Law


Receptor-Dependent Vascular Stress in Diabetes, 93
Ann Marie Schmidt, Barry I. Hudson, Shi-Fang Yan, and David M. Stern


Genetic Determinants of Late Diabetic Complications, 111
Alessandro Doria, James H. Warram, and Andrzej S. Krolewski


Diabetic Retinopathy and Vascular Endothelial Growth Factor, 133
Hans-Peter Hammes and Georg Breier

Part II Clinical Topics

Epidemiology of Diabetes Mellitus and Cardiovascular Disease, 153
Sunil V. Rao and Darren K. McGuire


Economic Implications of Diabetes Mellitus, 179
John D. Nachtigal and Cathryn A. Carroll


Obesity, 199
Mark W. Conard and Walker S. Carlos Poston


Diabetes Treatment, 219
William L. Isley


Endothelial Dysfunction, 239
Joshua A. Beckman


Platelet Dysfunction, 251
Robert Kelly and Steven R. Steinhubl


Diabetes, Impaired Fibrinolysis, and Thrombosis, 269
Peter J. Grant and Lucinda K.M. Summers


Restenosis, 293
David S. Lee and Marc S. Penn


The Renin-Angiotensin System, Nephropathy, and Hypertension, 315
Roberto Trevisan and Giancarlo Viberti


Lipoprotein Abnormalities, 337
William L. Isley and William S. Harris


Diabetes Mellitus and Ischemic Heart Disease, 355
Benjamin H. Trichon and Matthew T. Roe


Diabetes and Coronary Revascularization, 379
Deepak P. Vivekananthan and Deepak L. Bhatt


Diabetes and Peripheral Artery Disease, 403
Roberto A. Corpus
Appendix A. Adjunctive Pharmacology of Diabetes: Chain of Evidence, 423
Maureen E. Knell, Jared T. Lurk, and Jennifer M. Roth

Appendix B. Synopsis of Major Cardiovascular Trials Involving Diabetic Patients, 469
Avinash Khanna

Subject Index, 487

Produkt-Details

• Erscheint lt. Verlag: 4.11.2003
• Verlagsort: Philadelphia
• Sprache: englisch
• Maße: 178 x 254 mm
• Gewicht: 1129 g
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
• ISBN-10: 0-7817-4053-3 / 0781740533
• ISBN-13: 978-0-7817-4053-1 / 9780781740531
• Zustand: Neuware