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Androgens and Androgen Receptor -

Androgens and Androgen Receptor

Mechanisms, Functions, and Clini Applications

Chawnshang Chang (Herausgeber)

Buch | Hardcover
503 Seiten
2002 | 2002 ed.
Springer-Verlag New York Inc.
978-1-4020-7188-1 (ISBN)
CHF 224,65 inkl. MwSt
Includes discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and potential clinical applications. This book covers the discovery and cloning; coregulators; related genes and their consensus DNA response elements; the connections of androgens to women's diseases; and so on.
Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications.
Key topics covered include:
-The discovery and cloning of the androgen receptor;
-Androgen receptor coregulators;
-Androgen related genes and their consensus DNA response elements;
-Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies;
-Cross-talk to other signal transduction systems;
-The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer.

This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

Chawnshang Chang, Ph.D., is the George Hoyt Whipple Distinguished Professor at the University of Rochester.

1. Androgen Biosynthesis and Degradation.- 2. Structural and Functional Analysis of the Androgen Receptor.- 3. Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity.- 4. Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors.- 5. Nongenomic Androgen Action.- 6. The Role of 5?-Reductase in Prostate Disease and Male Pattern Baldness.- 7. Natural Products and Environmental Androgens/Antiandrogens.- 8. Androgens in Prostate Cancer and Benign Prostatic Hypoplasia.- 9. The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications.- 10. Androgen Receptor with Expanded Poly-Q Length in SBMA (Kennedy Disease).- 11. Androgen Insensivity Syndrome (Testicular Feminization).- 12. Androgens in Immunology and Autoimmune Diseases.- 13. Androgens in Penile Development, Penile Erection and Erectile Dysfunction.- 14. Androgens and the Androgen Receptor in Male Sex Development and Fertility.- 15. Androgens and Brain Function: Behavioral Perspectives.- 16. Androgens, Skeletal Homeostasis, and Osteoporosis.- 17. Androgens and Coronary Artery Disease.- 18. Androgen Therapy in Nonendocrine Illnesses.- 19. Androgens and Androgen Receptor in Dermatology.- 20. Androgen Deficiency and Abnormality in Women.

Erscheint lt. Verlag 31.10.2002
Zusatzinfo XIV, 503 p.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Studium 1. Studienabschnitt (Vorklinik) Physiologie
Veterinärmedizin Klinische Fächer Pathologie
ISBN-10 1-4020-7188-4 / 1402071884
ISBN-13 978-1-4020-7188-1 / 9781402071881
Zustand Neuware
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