Androgens and Androgen Receptor

Mechanisms, Functions, and Clini Applications

Buch | Softcover

503 Seiten

2012 | Softcover reprint of the original 1st ed. 2002
Springer-Verlag New York Inc.
978-1-4613-5422-2 (ISBN)

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Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications.
Key topics covered include:
-The discovery and cloning of the androgen receptor;
-Androgen receptor coregulators;
-Androgen related genes and their consensus DNA response elements;
-Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies;
-Cross-talk to other signal transduction systems;
-The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer.

This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

Chawnshang Chang, Ph.D., is the George Hoyt Whipple Distinguished Professor at the University of Rochester.

1. Androgen Biosynthesis and Degradation.- 2. Structural and Functional Analysis of the Androgen Receptor.- 3. Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity.- 4. Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors.- 5. Nongenomic Androgen Action.- 6. The Role of 5?-Reductase in Prostate Disease and Male Pattern Baldness.- 7. Natural Products and Environmental Androgens/Antiandrogens.- 8. Androgens in Prostate Cancer and Benign Prostatic Hypoplasia.- 9. The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications.- 10. Androgen Receptor with Expanded Poly-Q Length in SBMA (Kennedy Disease).- 11. Androgen Insensivity Syndrome (Testicular Feminization).- 12. Androgens in Immunology and Autoimmune Diseases.- 13. Androgens in Penile Development, Penile Erection and Erectile Dysfunction.- 14. Androgens and the Androgen Receptor in Male Sex Development and Fertility.- 15. Androgens and Brain Function: Behavioral Perspectives.- 16. Androgens, Skeletal Homeostasis, and Osteoporosis.- 17. Androgens and Coronary Artery Disease.- 18. Androgen Therapy in Nonendocrine Illnesses.- 19. Androgens and Androgen Receptor in Dermatology.- 20. Androgen Deficiency and Abnormality in Women.

Zusatzinfo	XIV, 503 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie
	Veterinärmedizin
ISBN-10	1-4613-5422-6 / 1461354226
ISBN-13	978-1-4613-5422-2 / 9781461354222
Zustand	Neuware