RNA Therapeutics

Buch | Softcover

VII, 259 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-88546-9 (ISBN)

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Computational Tools for Design of Selective Small Molecules Targeting RNA: From Small Molecule Microarrays to Chemical Similarity Searching.- A Modular Approach to the Discovery and Affinity Maturation of Sequence-Selective RNA-Binding Compounds.- Structure-Based Discovery of Small Molecules Binding to RNA.- Approaches for the Discovery of Small Molecule Ligands Targeting microRNAs.- Viral RNA Targets and Their Small Molecule Ligands.- Drugging Pre-mRNA Splicing.- Targeting RNA G-Quadruplexes for Potential Therapeutic Applications.- The Therapeutic Targeting of Long Noncoding RNA.- Messenger RNA as a Novel Therapeutic Approach.

Erscheint lt. Verlag	15.8.2018
Reihe/Serie	Topics in Medicinal Chemistry
Zusatzinfo	VII, 259 p. 45 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	415 g
Themenwelt	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik
Schlagworte	G-quadruplexes • lncRNAs • long non-coding RNAs • MicroRNAs • mRNAsplicing • Therapeutic Approach • viral RNAs
ISBN-10	3-319-88546-4 / 3319885464
ISBN-13	978-3-319-88546-9 / 9783319885469
Zustand	Neuware