Alagille Syndrome (eBook)

Pathogenesis and Clinical Management

Binita M. Kamath, Kathleen M. Loomes (Herausgeber)

eBook Download: PDF

2018 | 1st ed. 2018
XIV, 198 Seiten
Springer International Publishing (Verlag)
978-3-319-94571-2 (ISBN)

Infos

This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.

Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.  

Binita M. Kamath, MBBChir MRCP MTR

The Hospital for Sick Children

Division of Gastroenterology, Hepatology and Nutrition 

Toronto, ON

Canada

Kathleen M. Loomes, MD

Children's Hospital of Philadelphia

Division of Gastroenterology, Hepatology and Nutrition

Department of Pediatrics

Philadelphia, PA

USA

 

Inhalt

1 The Alagille Syndrome: Overview and IntroductionDavid Piccoli2 Bile Duct Development and the Notch Signaling PathwayStacey S. Huppert, Kathleen M. Campbell3 Genetics of Alagille SyndromeMelissa A. Gilbert, Nancy B. Spinner4 Liver Disease in Alagille SyndromeAlyssa Kriegermeier, Andrew Wehrman, Binita M. Kamath, Kathleen M. Loomes5 Transplant Considerations in Alagille SyndromeEvelyn Hsu, Elizabeth Rand6 Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille SyndromeJustin T. Tretter, Doff B. McElhinney7 Vascular Manifestations in Alagille SyndromeShannon M. Vandriel, Rebecca N. Ichord, Binita M. Kamath8 The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney DevelopmentRené Romero9 Skeletal Involvement in Alagille SyndromeYadav Wagley, Troy Mitchell, Jason Ashley, Kathleen M. Loomes, Kurt Hankenson10 Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving PhenotypeAlastair Baker11 Health-Related Quality of Life and Neurocognition in Alagille SyndromeSaeed Mohammad, Estella M Alonso12 Future Therapeutic Approaches for Alagille Syndrome Emma R. Andersson

Produkt-Details

• Erscheint lt. Verlag: 26.9.2018
• Zusatzinfo: XIV, 198 p. 41 illus., 31 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Schlagworte: bile duct development • complex biliary diseases • hepatology • immune system • notch signaling pathway • Transplant
• ISBN-10: 3-319-94571-8 / 3319945718
• ISBN-13: 978-3-319-94571-2 / 9783319945712