Nicht aus der Schweiz? Besuchen Sie lehmanns.de
Mitochondrial DNA and Diseases -

Mitochondrial DNA and Diseases (eBook)

Hongzhi Sun, Xiangdong Wang (Herausgeber)

eBook Download: PDF
2017 | 1st ed. 2017
VII, 230 Seiten
Springer Singapore (Verlag)
978-981-10-6674-0 (ISBN)
Systemvoraussetzungen
149,79 inkl. MwSt
(CHF 146,30)
Der eBook-Verkauf erfolgt durch die Lehmanns Media GmbH (Berlin) zum Preis in Euro inkl. MwSt.
  • Download sofort lieferbar
  • Zahlungsarten anzeigen

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA-associated diseases.



Dr. Hongzhi Sun is Professor and President of Jinzhou Hospital, Jinzhou Medical University, Jinzhou, Liaoning Province, China.

Dr. Xiangdong Wang is Distinguished Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.


The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinicalstudents and researchers in the field of mtDNA-associated diseases.

Dr. Hongzhi Sun is Professor and President of Jinzhou Hospital, Jinzhou Medical University, Jinzhou, Liaoning Province, China.Dr. Xiangdong Wang is Distinguished Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

How far can mitochondrial DNA drive the disease?.- Mitochondrial DNA in lung cancer.- Approach, application and bioethics of mtDNA sequencing in cancer.- Roles of mitochondrial DNA signaling in immune responses.- Mitochondrial DNA in Telocytes.- Roles of mitochondrial DNA in energy metabolism.- The role of base excision repair in maintaining mitochondrial DNA stability.- Is mitochondrial cell fragility a cell weakness?.- Mitochondrial DNA methylation and related disease.- Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis.- Metabolic regulation in mitochondria and drug resistance.- Mitochondrial Lon Protease and Cancer.- Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology.-Epithelial mitochondrial dysfunction in lung disease.

Erscheint lt. Verlag 25.11.2017
Reihe/Serie Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology
Zusatzinfo VII, 230 p. 89 illus., 62 illus. in color.
Verlagsort Singapore
Sprache englisch
Themenwelt Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Biologie Zellbiologie
Schlagworte Lung Diseases • mitochondria and metabolism • Mitochondrial DNA • mitochondrial DNA repair • mitochondrial homeostasis
ISBN-10 981-10-6674-4 / 9811066744
ISBN-13 978-981-10-6674-0 / 9789811066740
Haben Sie eine Frage zum Produkt?
PDFPDF (Wasserzeichen)
Größe: 6,6 MB

DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasser­zeichen und ist damit für Sie persona­lisiert. Bei einer missbräuch­lichen Weiter­gabe des eBooks an Dritte ist eine Rück­ver­folgung an die Quelle möglich.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich

von Berit Hackenberg; Anja Hohmann

eBook Download (2023)
Urban & Fischer Verlag - Lehrbücher
CHF 26,35
Leber, Gallenwege und Pankreas

von Andrea Tannapfel; Günter Klöppel

eBook Download (2020)
Springer Berlin Heidelberg (Verlag)
CHF 289,95