Pathology of Liver Diseases (eBook)

Gary C. Kanel (Autor)

eBook Download: PDF

2017
John Wiley & Sons (Verlag)
9781118895023 (ISBN)

Infos

Pathology of Liver Diseases is a rapid reference consultation tool that uses both book and online material to present a whole range of liver disorders. The book emphasizes not only the pathology seen in biopsy and surgical material, but also the most pertinent clinical and laboratory findings including epidemiology, etiologic and pathophysiologic concepts, and the differential diagnoses. Key references appear at the end of each chapter.
The book is also accompanied by a companion website: www.wiley.com/go/kanel/liverpathology

It contains the following online material:

• A complete Reference List.
• A Library that contains over 860 images of the various liver diseases, which adds to over 540 images that are in the book itself
• Additional Tables that address in detail the grading and staging of various liver diseases such as viral
  hepatitis and fatty liver diseases.
• 140 Case Examples, which include over 420 images that demonstrate the various ways many of these disease entities clinically present.
• A PowerPoint presentation entitled 'Liver Transplantation - Surgical Procedure', which includes photographs from the operating table of the step-by-step process in liver transplantation.

Pathology of Liver Diseases provides gastroenterologists and pathologists with a multi-media, well-illustrated, and concise guide to the pathology and clinical diagnoses of liver disorders.

Gary C. Kanel, M.D., Clinical Professor of Pathology, Keck Medical Center of USC, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA

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Pathology of Liver Diseases is a rapid reference consultation tool that uses both book and online material to present a whole range of liver disorders. The book emphasizes not only the pathology seen in biopsy and surgical material, but also the most pertinent clinical and laboratory findings including epidemiology, etiologic and pathophysiologic concepts, and the differential diagnoses. Key references appear at the end of each chapter. The book is also accompanied by a companion website: www.wiley.com/go/kanel/liverpathology It contains the following online material: A complete Reference List. A Library that contains over 860 images of the various liver diseases, which adds to over 540 images that are in the book itself Additional Tables that address in detail the grading and staging of various liver diseases such as viralhepatitis and fatty liver diseases. 140 Case Examples, which include over 420 images that demonstrate the various ways many of these disease entities clinically present. A PowerPoint presentation entitled "e;Liver Transplantation Surgical Procedure"e;, which includes photographs from the operating table of the step-by-step process in liver transplantation. Pathology of Liver Diseases provides gastroenterologists and pathologists with a multi-media, well-illustrated, and concise guide to the pathology and clinical diagnoses of liver disorders.

Inhalt

Pathology of Liver Diseases 3
Contents 7
Preface 8
About the companion website 10
1 Normal Liver 11
Embryology 11
Gross Anatomy 13
Histology 14
Basic Architecture Arrangement 14
Portal Tracts 15
Parenchyma 16
Stroma (Extracellular Matrix) 20
Biliary Network 21
Vascular and Lymphatic Networks 22
Neural Network 24
Structural and Functional Components 24
Progenitor and Stem Cells 24
Evaluating a Liver Biopsy Specimen 25
Indications for Liver Biopsy 25
Organizational Approach in Liver Biopsy Evaluation 26
Routine and Special Histologic Stains in Liver Biopsy Specimens 27
Routine Laboratory Tests Aiding in Liver Biopsy Evaluation 27
Special Laboratory Tests 33
Selected Reading 33
2 Viral Hepatitis 34
Viral Hepatitis Secondary to Infection by the Hepatotropic Viruses 34
General Characteristics and Clinical Presentations 34
Virology 37
Epidemiology and Serology (see Tables 2.1 and 2.2) 38
Pathology (see Table 2.3) 41
Systemic Viruses that Involve the Liver 53
Epstein–Barr Virus 53
Cytomegalovirus 55
HIV-associated Liver Diseases 56
Other Viruses Associated with Liver Disease 57
Selected Reading 59
3 Fatty Liver Diseases 60
Steatosis 60
Alcoholic Liver Disease 61
Epidemiology 61
Ethanol Metabolism 62
Pathophysiology 63
Natural History 66
Clinical Presentation 66
Pathology 67
Non-Alcoholic Fatty Liver Disease 73
Epidemiology 73
Pathophysiology 74
Clinical Presentation 75
Pathology 76
Scoring Systems in Non-Alcoholic Fatty Liver Disease 78
Differential Diagnoses of Alcoholic Liver Disease and Non-Alcoholic Fatty Liver Disease 78
Glycogenic Hepatopathy – Variant of Non-Alcoholic Fatty Liver Disease 80
Selected Reading 81
4 Diseases of the Biliary Tract 82
Primary Biliary Cirrhosis 83
Epidemiology 83
Pathophysiology and the Mitochondrial Antibody 83
Natural History and Clinical Presentation 84
Pathology 85
Primary Sclerosing Cholangitis 89
Epidemiology and Natural History 89
Pathophysiology 89
Clinical Presentation 90
Pathology 91
Extrahepatic and Large Intrahepatic Mechanical Bile Duct Obstruction 93
Causes and Clinical Course 94
Pathology 95
Secondary (Acquired) Sclerosing Cholangitis 99
Differential Diagnoses of Diseases of the Biliary Tract 101
Other Causes of Interlobular Bile Duct Loss (Ductopenia) 103
Selected Reading 103
5 Non-Viral Infectious Diseases 105
Gram-positive and Gram-negative Bacteria 105
Bacteremia and Pyogenic Abscesses 105
Salmonellosis 107
Other Bacteria Causing Liver Disease 109
Rickettsia 111
Q-fever 111
Rocky Mountain Spotted Fever 112
Boutonneuse Fever 113
Spirochetes 113
Syphilis 113
Borrelia species infection 115
Leptospirosis 115
Mycobacterium 115
Tuberculosis 115
Leprosy 117
Mycobacterium-avium Complex 118
Fungi 118
Aspergillosis 118
Blastomycosis 119
Coccidioidomycosis 119
Candidiasis 119
Cryptococcosis 120
Histoplasmosis 121
Brazilian Blastomycosis 122
Mucormycosis 122
Parasites (Protozoa, Helminths) 122
Amebiasis 122
Malaria 124
Echinococcosis 125
Schistosomiasis 126
Toxoplasmosis 128
Clonorchiasis, Opisthorchiasis 128
Toxocariasis 129
Other Parasitic Infestations 130
Differential Diagnoses 131
Selected Reading 132
6 Granulomatous Hepatitis 133
Sarcoidosis 136
Epidemiology 136
Clinical Presentation 136
Pathogenesis 137
Pathology 137
Differential Diagnoses 139
Chronic Granulomatous Disease 139
Selected Reading 139
7 Autoimmune Hepatitis 141
Epidemiology 141
Pathogenesis 141
Autoimmune Serologies and Classifications 143
Clinical Presentation 144
Pathology 145
Autoimmune Variants and “Overlap Syndromes” 148
Histologic Scoring Systems 150
Differential Diagnoses 151
Selected Reading 151
8 Vascular Disorders 153
Hepatic Veins 153
Budd–Chiari Syndrome 153
Right-Sided (Congestive) Heart Failure 156
Portal Veins 159
Portal Vein Thrombosis 159
Non-Cirrhotic Portal Fibrosis (“Non-Cirrhotic Portal Hypertension”) 161
Hepatic Artery and Systemic Circulation 163
Hepatic Artery Hypoperfusion and Hypoxia, Vasculitis, Hepatic Artery Thrombosis 163
Heat Stroke and Hyperpyrexia 165
Hepatic Sinusoids 166
Sinusoidal Obstruction Syndrome (Venoocclusive Disease) 166
Peliosis Hepatis and the Angioproliferative Lesions 168
Sinusoidal Infiltrates Associated with Vascular Impairment 169
Acquired, Developmental and Hereditary Vascular Shunts 170
Selected Reading 171
9 Genetic and Metabolic Hepatic Diseases 172
?1-Antitrypsin Deficiency (Disorder of the Endoplasmic Reticulum) 172
Epidemiology 172
Physiology, Pathophysiology, and Gene Mutations 172
Clinical Presentation 173
Pathology 173
Differential Diagnoses 175
Cystic Fibrosis (Mucoviscoidosis) 176
Epidemiology 176
Pathophysiology and Gene Mutations 176
Clinical Presentation 176
Pathology 177
Differential Diagnoses 177
Porphyrias 178
Porphyria Cutanea Tarda 178
Erythropoietic Protoporphyria 180
Disorders Associated with Increase in Hepatic Iron 181
Iron Metabolism 181
Hereditary Hemochromatosis 182
Copper Storage Disorders 186
Copper Metabolism 186
Wilson Disease 187
Hereditary Hyperbilirubinemias 192
Familial Forms of Intrahepatic Cholestasis (Variants of Progressive Familial Intrahepatic Cholestasis 194
Storage Diseases 194
Carbohydrate Metabolism Storage Diseases 194
Gaucher Disease 199
Niemann–Pick Disease 201
Miscellaneous Storage Diseases 202
Disorders of Amino Acid Metabolism 202
Hereditary Tyrosinemia 202
Other Disorders of Amino Acid Metabolism 204
Mitochondrial Fatty Acid Oxidation Disorders 204
Sickle Cell Anemia 205
Epidemiology, Pathophysiology and Gene Mutations 205
Clinical Presentation 205
Pathology 206
Selected Reading 207
10 Developmental Hepatobiliary Disorders and Cystic Diseases 208
Neonatal Hepatitis 208
Biliary Atresia 209
Extrahepatic Biliary Atresia 210
Intrahepatic Biliary Atresia (Paucity of Ducts) 212
Developmental and Congenital Cystic Diseases of the Intra- and Extrahepatic Biliary System 214
Choledochal Cyst 216
Fibrocystic Diseases 217
Simple Hepatic Cysts 217
Peribiliary Cysts 219
Von Meyenburg Complex (Biliary Micro-hamartoma) 219
Polycystic Liver Disease 219
Selected Reading 224
11 Drug- and Toxin-Induced Liver Diseases 225
Overview of Drug- and Toxin-Induced Injury 225
Type of Liver Injury 225
Pathogenesis 226
Risk Factors 226
Diagnosis 227
Hepatocellular Necrosis with Minimal to Absent Necroinflammatory Change 228
Acute Hepatocellular Necroinflammatory Change 229
Chronic Hepatocellular Necroinflammatory Change 231
Steatosis and Steatohepatitis 233
Granulomas 234
Mallory–Denk Bodies 235
Acute Cholestatic Liver Injury 236
Chronic Cholestatic Liver Injury 237
Vascular Injury 237
Neoplasms and Related Lesions 238
Pigments and Miscellaneous Conditions 239
Selected Reading 240
12 Liver Transplantation 241
Introduction with Indications for Liver Transplantation and Patient Selection 241
Evaluation of the Donor Liver 243
General Sequence of Events After Liver Transplantation 244
Harvesting (Preservation) Injury 244
Pathology 245
Differential diagnoses 246
Acute Graft Failure (Primary Non-Function) 246
Pathology 246
Differential Diagnoses 247
Rejection 247
Antibody-mediated (humoral) rejection 247
Acute (Cellular) Rejection 248
Chronic (Ductopenic) Rejection 252
Post-Transplant Complications 255
Infections 255
Bacterial and Fungal Infections 255
Viral Infections 255
Biliary tract strictures 259
Vascular Injury 260
Recurrent Disease Post-Transplant 262
Recurrent Viral Hepatitis 262
Recurrent Cholestatic Liver Diseases 266
Recurrent Primary Biliary Cirrhosis 266
Recurrent Primary Sclerosing Cholangitis 267
Recurrent Autoimmune Hepatitis 268
Recurrent Fatty Liver Diseases 269
Malignancies Post-Transplant 271
Recurrent Hepatocellular Carcinoma 271
De Novo Malignancies 271
Latent and Acquired (De Novo) Liver Disease 272
Graft-Versus-Host Disease 273
Selected Reading 275
13 Hepatic Tumors, Benign 276
Hepatocellular Adenoma (Liver Cell Adenoma) 276
Epidemiology and Clinical Presentation 276
Pathogenesis with Gene Alterations and Mutations 277
Pathology 278
Fine Needle Aspiration Cytology 281
Immunohistochemical Staining Patterns 281
Differential Diagnoses 281
Focal Nodular Hyperplasia 283
Epidemiology and Clinical Presentation 283
Pathology 283
Fine Needle Aspiration Cytology 284
Immunohistochemical Staining Patterns 285
Differential Diagnoses 285
Cavernous Hemangioma 285
Epidemiology and Clinical Presentation 285
Pathology 286
Differential Diagnoses 287
Hepatobiliary Cystadenoma 288
Pathology 288
Differential Diagnoses 288
Infantile Hemangioendothelioma 289
Pathology 289
Differential Diagnoses 290
Inflammatory Pseudotumor 291
Pathology 291
Differential Diagnoses 292
Nodular Regenerative Hyperplasia 292
Pathology 293
Differential Diagnoses 293
Other Benign Hepatic Tumors 294
Selected Reading 298
14 Hepatic Tumors, Malignant 299
Hepatocellular Carcinoma 299
Epidemiology 299
Etiologic Factors (Table 14.2) 300
Pathophysiology (Table 14.3) 303
Clinical Presentation 304
Pathology 305
Fine Needle Aspiration Cytology 310
Tumor grading 310
Immunohistochemistry 312
Differential Diagnoses 314
Fibrolamellar Hepatocellular Carcinoma 316
Pathology 316
Differential Diagnoses 317
Cholangiocarcinoma 317
Epidemiology 317
Etiologic Factors (Table 14.5) 318
Pathophysiology 319
Clinical Presentation 320
Pathology 320
Fine Needle Aspiration Cytology 323
Immunohistochemistry 323
Differential Diagnoses 323
Combined Hepatocellular – Cholangiocarcinoma 325
Hepatoblastoma 326
Epidemiology and Pathophysiology 326
Clinical Features 326
Pathology 326
Fine Needle Aspiration Cytology 328
Differential Diagnoses 328
Malignant Vascular Tumors 328
Angiosarcoma 328
Epithelioid Hemangioendothelioma (Vasoablative Endotheliosarcoma) 330
Rare Primary Malignant Hepatic Neoplasms 331
Hematopoietic Neoplasms with Hepatic Involvement 333
Lymphoma, Hodgkin Disease 333
Lymphoma, Non-Hodgkin Disease 334
Leukemia, Myeloproliferative Disorders 336
Plasma Cell Dyscrasias 337
Langerhans Cell Histiocytosis 338
Metastatic Tumors 340
Macroregenerative and Dysplastic Cirrhotic Nodules 342
Selected Reading 346
15 Miscellaneous Hepatic Disorders 347
Amyloidosis 347
Epidemiology 347
Pathophysiology and Classifications 347
Clinical Presentation 347
Pathology 348
Special Staining Patterns 350
Differential Diagnoses 351
Inflammatory Bowel Diseases and the Liver 351
Reye Syndrome 352
Epidemiology 352
Clinical Presentation and Pathophysiology 353
Pathology 353
Differential Diagnoses 354
Liver Diseases Associated with Pregnancy 354
Acute Fatty Liver of Pregnancy 354
Toxemia of Pregnancy 356
Hemolysis, Elevated Liver Enzymes, Low Platelet (HELLP) syndrome 356
Benign Intrahepatic Cholestasis of Pregnancy 357
Total Parenteral Nutrition Induced Liver Injury (Hyperalimentation) 357
Epidemiology and Clinical Presentation 358
Pathogenesis 358
Pathology 358
Differential Diagnoses 359
Other Miscellaneous Conditions 360
Non-Specific Reactive Hepatitis 360
Hemophagocytic Lymphohistiocytosis 361
Other Disorders 361
Selected Reading 363
Index 364
EULA 387

Rezensionen

"This is a great addition to liver pathology books. It will be extremely helpful for residents and practicing pathologists who are looking for a book on the practical approach to liver biopsy and resection specimens. The text is descriptive, yet concise and easy to read; the pictures are high quality and the picture legends are helpful in describing the pertinent microscopic details. It is highly recommended for all practicing surgical pathologists" Doody's, October 2017

Produkt-Details

• Erscheint lt. Verlag: 27.2.2017
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Schlagworte: biopsy • Book • chapter normal • Companion • Diseases • disorders • emphasizes • Fatty • Gastroenterologie • Gastroenterologie u. Hepatologie • Gastroenterology & Hepatology • hepatic • Hepatologie • hepatology • Index • Lebererkrankung • Liver • Malignant • Medical Science • Medizin • Miscellaneous • Pathologie • Pathology • Rapid • reference consultation • surgical • vi • Viral Hepatitis
• ISBN-13: 9781118895023 / 9781118895023