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Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology -

Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology (eBook)

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2014 | 2015
X, 229 Seiten
Springer New York (Verlag)
978-1-4939-1607-8 (ISBN)
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This volume provides a practical yet comprehensive guide to manage the shift in the diagnosis of lung cancer from large resections to small samples, including cytology specimens and core biopsies. Specifically, it outlines various available minimally-invasive modalities and presents algorithms to optimize and maximize sample collection and processing beginning at the time of tissue acquisition during the procedure. Secondly, the book provides an overview of the various existing and emerging lung cancer therapies and why a specific diagnosis is crucial. Key elements for the classification of small biopsies and cytology proposed by the ATS, IASLC, and ERS are highlighted. A section dedicated to immunohistochemistry offers a logical, step-by-step guide to sub-classify lung cancers and to differentiate them from metastases. The text also provides a review of the various molecular tests (and alternatives in cases of scant tissue) required for lung adenocarcinomas. Finally, potential pitfalls to avoid during acquisition, processing, and classification are discussed.

With contributions from a team of multidisciplinary authors who are regularly involved in the care of lung cancer patients , Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology is an invaluable reference guide for pathologists, pathologists-in-training, and allied professionals, including oncologists, pulmonologists, surgeons, and radiologists. ​



Andre Luis Moreira, MD, PhD
Memorial Sloan Kettering Cancer Center, Department of Pathology, New York, New York, USA

Anjali Saqi, MD, MBA
Columbia University Medical Center, Department of Pathology and Cell Biology, New York-Presbyterian Hospital, New York, New York, USA


This volume provides a practical yet comprehensive guide to manage the shift in the diagnosis of lung cancer from large resections to small samples, including cytology specimens and core biopsies. Specifically, it outlines various available minimally-invasive modalities and presents algorithms to optimize and maximize sample collection and processing beginning at the time of tissue acquisition during the procedure. Secondly, the book provides an overview of the various existing and emerging lung cancer therapies and why a specific diagnosis is crucial. Key elements for the classification of small biopsies and cytology proposed by the ATS, IASLC, and ERS are highlighted. A section dedicated to immunohistochemistry offers a logical, step-by-step guide to sub-classify lung cancers and to differentiate them from metastases. The text also provides a review of the various molecular tests (and alternatives in cases of scant tissue) required for lung adenocarcinomas. Finally, potential pitfalls to avoid during acquisition, processing, and classification are discussed. With contributions from a team of multidisciplinary authors who are regularly involved in the care of lung cancer patients , Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology is an invaluable reference guide for pathologists, pathologists-in-training, and allied professionals, including oncologists, pulmonologists, surgeons, and radiologists. ?

Andre Luis Moreira, MD, PhDMemorial Sloan Kettering Cancer Center, Department of Pathology, New York, New York, USAAnjali Saqi, MD, MBAColumbia University Medical Center, Department of Pathology and Cell Biology, New York-Presbyterian Hospital, New York, New York, USA

Chapter 1Histological Classification and Its Need for Treatment of Lung CancerAndre Luis Moreira and William D. Travis Chapter 2Advances in Non-surgical Sampling Techniques for the Diagnosis and Staging of Lung Cancer David F. Yankelevitz and William BulmanChapter 3Adequacy and Tissue Preservation of Small Biopsy and Cytology SpecimensJohn P. Crapanzano and Anjali SaqiChapter 4Optimization and Triage of Small SpecimensAnjali Saqi and John P. Crapanzano Chapter 5Ancillary Immunohistochemical Techniques for the Subclassification of Non-small Cell Lung CancerDaisuke Nonaka Chapter 6Adequacy and Utilization of Small Biopsy Material for Molecular DiagnosisGilda da Cunha SantosChapter 7Role of Immunohistochemistry in the Detection of Targetable Mutations Andre Luis MoreiraChapter 8New Discoveries for the Treatment of Lung Cancer and the Role of Small Biopsy MaterialJuliana Eng, Alexander E. Drilon, Paul K. PaikChapter 9Evaluation of Small Biopsy Material in Patients with Multiple and Secondary TumorsSara E. Monaco and Sanja Dacic Chapter 10 Common Benign Mimickers of Lung Carcinoma in Cytology and Small Biopsy SpecimensElena Lucas and Sunati Sahoo

Erscheint lt. Verlag 7.10.2014
Zusatzinfo X, 229 p. 81 illus., 80 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizinische Fachgebiete Innere Medizin Pneumologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 2. Studienabschnitt (Klinik) Pathologie
Schlagworte lung aspiration biopsy • Lung Cancer • mimickers of carcinoma • tissue acquisition
ISBN-10 1-4939-1607-6 / 1493916076
ISBN-13 978-1-4939-1607-8 / 9781493916078
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