Complex Structure and Dynamics of the Heart (eBook)

Philip Bittihn (Autor)

eBook Download: PDF

2014 | 2015
XV, 204 Seiten
Springer International Publishing (Verlag)
978-3-319-12232-8 (ISBN)

Infos

This award-winning thesis investigates the mechanisms underlying cardiac arrhythmia development and termination from an entirely new perspective. By viewing the heart as a complex system, the author uses theoretical tools from nonlinear dynamics combined with numerical simulations and experiments to achieve insights into the relationship between its structure and dynamics, thereby paving the way towards innovative low-energy defibrillation strategies. The work tackles, among other things: the effect of substrate heterogeneity on the spatial-temporal dynamics of cardiac arrhythmias and ways in which weak pulsed electric fields can be used to control these dynamics in heterogeneous cardiac tissue. The long-term vision of this research is to replace the current strategy of applying painful and sometimes tissue damaging electric shock - currently the only reliable way to terminate life-threatening fibrillation - by a more subtle but equally effective intervention. The book maps out a number of promising research directions for biophysicists and medical researchers working on the origins and treatment of cardiac arrhythmias.

Dr. Philip Bittihn studied physics at the Georg-August-Universität Göttingen as a scholar of the Studienstiftung des deutschen Volkes (German National Academic Foundation). In 2009, he obtained his diploma with honors from the university, before joining the MPRG Biomedical Physics at the Max Planck Institute for Dynamics and Self-Organization, Göttingen. He received his PhD in June 2013 for theoretical and experimental work on the complex structure and dynamics of the heart and is currently a postdoctoral scholar at the BioCircuits Institute, University of California, San Diego. His interests include the nonlinear dynamics and emergent phenomena of biological systems, numerical simulations, partial differential equations and experimental data analysis.

Inhalt

Introduction.- Methods.- Results.- Conclusion.- Appendix A Modeling Details.- Appendix B Supplementary Data.- Appendix C MediaSim -- An Open Framework for Simulating Extended Systems.- Index.

Produkt-Details

• Erscheint lt. Verlag: 27.12.2014
• Reihe/Serie: Springer Theses
• Reihe/Serie: Springer Theses
• Zusatzinfo: XV, 204 p. 69 illus., 47 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Themenwelt: Technik
• Schlagworte: Cardiac Dynamics • Electric-field-based Control Strategies • Fibrillation and Defibrillation • Heart as a Complex System • Heart Muscle as Excitable Medium • Mathematical Models of Cardiac Tissue • Numerical Simulations of Heart Dynamics
• ISBN-10: 3-319-12232-0 / 3319122320
• ISBN-13: 978-3-319-12232-8 / 9783319122328