Pulmonary Deposition and Retention of Inhaled Aerosols (eBook)

Paul Gross, Theodore F. Hatch (Autoren)

George D. Clayton (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
208 Seiten
Elsevier Science (Verlag)
978-1-4832-5852-2 (ISBN)

Infos

Pulmonary Deposition and Retention of Inhaled Aerosols is concerned with the respiratory deposition and retention of inhaled aerosols, starting with initial intake and concluding with events that precede pathological tissue response, drawing equally upon both the physical and biological aspects of the subject. The book opens with an introductory chapter on the relationship between the dose of an inhaled aerosol and the kind and degree of response, and classification of particulate substances. This is followed by separate chapters on pulmonary deposition and retention of inhaled aerosols; the factors that influence disease risks associated with atmospheric exposure to aerosols; and measurement of aerosol composition and concentration. It is hoped that the book will help the specialists from both sides as well as technical and administrative personnel to acquire a common understanding of the important intermediate factors that operate between the outside dusty atmosphere and the internal tissue damage and disease-factors that may operate to make one exposure dangerous to life and another altogether innocuous.

Inhalt

Front Cover 1
Pulmonary Deposition and Retention of Inhaled Aerosols 4
Copyright Page 5
Table of Contents 12
FOREWORD 6
PREFACE 10
GLOSSARY 14
CHAPTER 1. Introduction 18
1. Dose-Response Relationship 20
2. Classification of Particulate Substances 22
CHAPTER 2. Anatomical and Physiological Factors in Respiratory Deposition of Aerosols 26
1. Anatomical Arrangement 27
2. Aerodynamics of Respiration 36
CHAPTER 3. Physical Factors in Respiratory Deposition of Aerosols 44
1. Formalized Arrangement of the Respiratory System and of Air Flow 45
2. Physics of Particle Deposition 48
3. Nasal Deposition 55
4. Limitations in Analyses 58
CHAPTER 4. Experimental Studies on Deposition of Inhaled Aerosols 62
1. Measurement of Total Respiratory Deposition 62
2. Measurement of Regional Deposition within the Respiratory System 73
3. Respiratory Deposition in Animals versus That in Man 82
CHAPTER 5. Pulmonary Clearance 86
1. Upper Respiratory Tract Clearance 87
2. Alveolar Clearance 91
CHAPTER 6. Experimental Studies on Pulmonary Clearance 104
1. Upper Respiratory Clearance 104
2. Clearance from the Pulmonary Air Spaces 105
3. Early Postexposure Clearance 106
4. Long-Term Clearance 108
5. Mobilization from Dust Deposits 118
6. Permanent Dust Deposits 118
7. Particle Transport to Lymph Nodes 122
8· Summary 132
CHAPTER 7. Disease Risk from Inhaled Aerosols 134
1. Pneumoconioses 134
2. Systemic Poisons 143
3. Radioactive Particulate Hazards 148
4. Allergic and Other Sensitivity Responses 152
5. Air-Borne Infection 154
6. Particulate Contaminants in Community Air Pollution 159
CHAPTER 8. Measurement of Respirable Aerosol Exposure 164
1. Measurement of Aerosol Composition and Concentration 164
2. Two-Stage versus Multistage Sampling 180
3. Method of Expressing Aerosol Concentration 187
References 190
AUTHOR INDEX 202
SUBJECT INDEX 207

Produkt-Details

• Erscheint lt. Verlag: 12.9.2013
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Technik
• ISBN-10: 1-4832-5852-1 / 1483258521
• ISBN-13: 978-1-4832-5852-2 / 9781483258522