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Biochemical and Neurophysiological Correlation of Centrally Acting Drugs -

Biochemical and Neurophysiological Correlation of Centrally Acting Drugs (eBook)

Second International Pharmacological Meeting
eBook Download: PDF
2013 | 1. Auflage
296 Seiten
Elsevier Science (Verlag)
978-1-4831-8538-5 (ISBN)
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Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 2: Biochemical and Neurophysiological Correlation of Centrally Acting Drugs focuses on the composition, reactions, and applications of centrally acting drugs. The selection first offers information on the physiology of striopallidum in relation to extrapyramidal function and disorders and actions of dopa and dopamine in relation to function of the central nervous system. Discussions focus on correlation of behavioral and clinical states with metabolism of dopamine, functions of dopamine in the brain, and the central pharmacology of dopamine. The text then examines the role of brain dopamine (3-hydroxytyramine) in Parkinsonism, including behavior of dopamine in the extrapyramidal centers in patients with Parkinson's disease; brain dopamine and the extrapyramidal symptomatology of Parkinson's disease; and parallelism between Parkinson's disease and the Parkinson-like state induced by reserpine in man. The publication ponders on pharmacological studies on tremorine and metabolism of tremorine. The manuscript also takes a look at the contribution on the pathophysiology of intentional tremor; failure of Antiparkinson drugs to antagonize hypothermia in tremorine-treated rats; and significance of dopamine in psychomotor stimulant action. The selection is a dependable source of data for readers interested in centrally acting drugs.
Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 2: Biochemical and Neurophysiological Correlation of Centrally Acting Drugs focuses on the composition, reactions, and applications of centrally acting drugs. The selection first offers information on the physiology of striopallidum in relation to extrapyramidal function and disorders and actions of dopa and dopamine in relation to function of the central nervous system. Discussions focus on correlation of behavioral and clinical states with metabolism of dopamine, functions of dopamine in the brain, and the central pharmacology of dopamine. The text then examines the role of brain dopamine (3-hydroxytyramine) in Parkinsonism, including behavior of dopamine in the extrapyramidal centers in patients with Parkinson's disease; brain dopamine and the extrapyramidal symptomatology of Parkinson's disease; and parallelism between Parkinson's disease and the Parkinson-like state induced by reserpine in man. The publication ponders on pharmacological studies on tremorine and metabolism of tremorine. The manuscript also takes a look at the contribution on the pathophysiology of intentional tremor; failure of Antiparkinson drugs to antagonize hypothermia in tremorine-treated rats; and significance of dopamine in psychomotor stimulant action. The selection is a dependable source of data for readers interested in centrally acting drugs.

Front Cover 1
Biochemical and Neurophysiological Correlation of Centrally Acting Drugs 4
Copyright Page 5
Table of Contents 6
LIST OF AUTHORS 8
PART 1: DRUGS INTERFERING WITH THE EXTRAPYRAMIDAL SYSTEM 10
CHAPTER 1. PHYSIOLOGY OF THE STRIOPALLIDUM IN RELATION TO EXTRAPYRAMIDAL FUNCTION AND DISORDERS 12
ACKNOWLEDGEMENT 32
REFERENCES 32
CHAPTER 2. ACTIONS OF DOPA AND DOPAMINE IN RELATION TO FUNCTION OF THE CENTRAL NERVOUS SYSTEM 44
A. INTRODUCTION 44
B. CENTRAL PHARMACOLOGY OF DOPAMINE 45
C. CORRELATION OF BEHAVIOURAL AND CLINICAL STATES WITH METABOLISM OF DOPAMINE 52
D. FUNCTIONS OF DOPAMINE IN THE BRAIN 55
ACKNOWLEDGEMENT 57
REFERENCES 57
CHAPTER 3. DOPAMINE IN THE CENTRAL NERVOUS SYSTEM 60
CHAPTER 4. THE ROLE OF BRAIN DOPAMINE (3-HYDROXYTYRAMINE) IN PARKINSONISM 66
BEHAVIOUR OF DOPAMINE IN THE EXTRAPYRAMIDAL CENTRES IN PATIENTS WITH PARKINSON'S DISEASE 66
BRAIN DOPAMINE AND THE EXTRAPYRAMIDAL SYMPTOMATOLOGY OF PARKINSON'S DISEASE 67
SPECIFICITY AND THE SITE OF ACTION OF L-DOPA IN PARKINSON'S DISEASE 68
PARALLELISM BETWEEN PARKINSON'S DISEASE AND THE PARKINSON-LIKE STATE INDUCED BY RESERPINE IN MAN 70
PHARMACOLOGICAL DIFFERENCES BETWEEN THE RESERPINE-INDUCED STATE AND THAT OF PARKINSON'S DISEASE IN THE PERIPHERY 72
DOES THERE EXIST AN ABNORMALITY OF THE OVER-ALL METABOLISM OF DOPAMINE IN PARKINSON'S DISEASE? 73
WHAT MAKES THE DOPAMINE IN THE EXTRAPYRAMIDAL CENTRES DISAPPEAR IN PARKINSON'S DISEASE? HYPOTHETICAL SUGGESTIONS 73
NOTE ADDED IN PROOF 77
CHAPTER 5. PHARMACOLOGICAL STUDIES ON TREMORINE 78
CHAPTER 6. THE METABOLISM OF TREMORINE 84
PHARMACOLOGY OF OXOTREMORINE 85
OTHER METABOLITES OF TREMORINE 85
CONCLUSIONS 88
REFERENCES 88
CHAPTER 7. CONTRIBUTION ON THE PATHOPHYSIOLOGY OF INTENTIONAL TREMOR 90
ACKNOWLEDGMENT 97
CHAPTER 8. MÉDICAMENTS AGISSANT SUR LA SYMPTOMATOLOGIE EXTRA-PYRAMIDALE DES NEUROLEPTIQUES 102
CHAPTER 9. FAILURE OF ANTIPARKINSON DRUGS TO ANTAGONIZE HYPOTHERMIA IN TREMORINE-TREATED RATS 114
CHAPTER 10. DE L'ANTAGONISME VIS-A-VIS DE DIFFÉRENTS EFFETS DE LA TRÉMORINE CHEZ LA SOURIS 118
CONCLUSIONS 123
CHAPTER 11. SIGNIFICANCE OF DOPAMINE IN PSYCHOMOTOR STIMULANT ACTION 124
INTRODUCTION 124
NEUROCHEMISTRY AND PATHOLOGY 124
STRUCTURE–ACTIVITY RELATIONS 126
DIRECT AND INDIRECT ACTION 128
DEPLETING AND RELOADING CATECHOLAMINE STORES 130
SELECTIVE DEPLETION OF NORADRENALINE STORES 133
CONCLUSION 133
ACKNOWLEDGEMENTS 134
REFERENCES 134
DISCUSSION TO PART I 136
PART 2: DRUGS INTERFERING WITH THERMOREGULATION 142
CHAPTER 12. THE PHYSIOLOGY AND PHARMACOLOGY OF TEMPERATURE REGULATION WITH PARTICULAR REFERENCE TO THE CHEMICAL MEDIATORS 144
CHAPTER 13. THE PHYSIOLOGY OF THERMOREGULATION 154
ACKNOWLEDGEMENT 161
CHAPTER 14. AN ANALYSIS OF HYPERTHERMIA INDUCED BY 5-HTP 164
METHODS 166
RESULTS AND DISCUSSION 169
SUMMARY 171
REFERENCES 171
CHAPTER 15. DROGUES HYPOTHERMISANTES 174
GÉNÉRALITÉS 174
I. PHYSIOLOGIE 175
II. LES DROGUES HYPOTHERMISANTES 187
I. ACTION HYPOTHERMISANTE POUR LAQUELLE UN MÉCANISME MÉTABOLIQUE PEUT ÊTRE INVOQUÉ ET INTÉGRÉ AUX DIFFÉRENTS NIVEAUX D'ORGANISATION 190
II. ACTION HYPOTHERMISANTE POUR LAQUELLE SEUL UN MÉCANISME NERVEUX PÉRIPHÉRIQUE PEUT ÊTRE ACTUELLEMENT INVOQUÉ 203
CHAPTER 16. ACTION DES INHIBITEURS DE LA L-DOPA/5 HTP DÉCARBOXYLASE EN HYPOTHERMIE 212
CHAPTER 17. PHARMACOLOGICAL STUDIES ON THE EFFECT CAUSED BY PYROGEN ON RABBITS 220
CHAPTER 18. CATECHOLAMINE-INDUCED ENDOTOXIN-LIKE FEVER 228
CHAPTER 19. THE ROLE OF AUTONOMIC NERVOUS FUNCTION IN MAMMALIAN THERMOREGULATION 234
CHAPTER 20. METABOLIC IMPLICATIONS OF COLD ADAPTATION 248
ACKNOWLEDGEMENT 255
REFERENCES 255
CHAPTER 21. ANTAGONISTES DE L'ACTION HYPERTHERMISANTE DU LYSERGAMIDE CHEZ LE LAPIN 258
MÉTHODE 259
RÉSULTATS 260
DISCUSSION 266
REMERCIEMENT 269
RÉSUMÉ 269
SUMMARY 269
CHAPTER 22. NEURO-STIMULANTS HALLUCINOGÈNES ET NON HALLUCINOGÈNES: CONFRONTATION EXPÉRIMENTALE DE LEURS EFFETS SUR LES TEMPÉRATURES CENTRALE ET PÉRIPHÉRIQUE 272
COMPARAISON AVEC LA MÉTHAMPHÉTAMINE 282
COMPARAISON AVEC LES PRÉCURSEURS DES AMINES BIOGÈNES 283
CONCLUSION 286
DISCUSSION TO PART II 288
INDEX 290

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