Neuropsychopharmacology (eBook)

Proceedings of the 7th International Congress of Pharmacology, Paris, 1978

C. Dumont (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
284 Seiten
Elsevier Science (Verlag)
978-1-4831-4665-2 (ISBN)

Infos

Advances in Pharmacology and Therapeutics, Volume 5: Neuropsychopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neuropsychopharmacology and cover topics ranging from anti-schizophrenic drugs to drug pathways in depression treatment. Pharmacological interferences with nonstriatal dopaminergic systems are also discussed. This volume is comprised of 21 chapters and opens by considering the nanomolar affinity of pre- and post-synaptic dopamine receptors for neuroleptics. The next section deals with drug pathways in the treatment of depression, with particular reference to the biochemical mechanisms of depressive states and the therapeutic effects of some antidepressants. The following chapters examine dopamine receptors in the nucleus accumbens; modulation of mesolimbic dopamine mechanisms via serotonin and GABA; how mesocortical dopaminergic neurons react to stress; and the behavioral consequences of the interaction between morphine, substance P, and nonstriatal dopamine neurons. This book will be of interest to practitioners in biosciences, pharmacology, physiology, psychology, neurology, and medicine.

Inhalt

Front Cover 1
Neuropsychopharmacology 4
Copyright Page 5
Table of Contents 6
Introduction 8
Part I: Invited Lectures 10
Chapter 1. Anti-schizophrenic Drugs: Membrane Receptor Sites of Action 12
SUMMARY 26
ACKNOWLEDGEMENTS 26
REFERENCES 26
Chapter 2. Pharmacology of Neurogenic Dystrophies Produced by Stress 30
ABSTRACT 30
REFERENCES 45
Chapter 3. Physiological and Pathophysiological Implications of the Retrograde Axonal Transport of Macromolecules 46
INTRODUCTION 46
RETROGRADE AXONAL TRANSPORT OF NGF MECHANISM AND PATHWAY OF TRANSPORT, PHYSIOLOGICAL IMPORTANCE
SPECIFICITY OF BINDING AND UPTAKE OF NGF, LECTINS AND TOXINS BY NERVE TERMINALS 55
UPTAKE AND RETROGRADE AXONAL TRANSPORT OF MACROMOLECULES AS A TOOL FOR QUANLITATIVE AND QUANTITATIVE CHARACTERIZATION OF NERVE TERMINAL MEMBRANES 56
PATHOPHYSIOLOGICAL IMPORTANCE OF RETROGRADE AXONAL AND TRANS-SYNAPTIC TRANSPORT OF TETANUS TOXIN 58
POSSIBLE THERAPEUTIC APPLICATIONS OF RETROGRADE AXONAL TRANSPORT 59
ACKNOWLEDGEMENTS 60
REFERENCES 60
Chapter 4. Opiate Analgesia: the Physiology and Pharmacology of Spinal Pain Systems 70
I. A direct inhibitory action of morphine at the spinal level 71
II. An action of morphine via brainstem mechanisms 75
CONCLUSION 82
REFERENCES 83
Chapter 5. Pharmacological Approaches for the Study of Neuro-endocrine Events 92
INTRODUCTION 92
II. LOCALIZATION OF HYPOTHALAMIC HORMONES 92
III. BEHAVIORAL EFFECTS OF HYPOTHALAMIC HORMONES 94
IV. INPUTS TO HYPOTHALAMIC NEURONS 94
ACKNOWLEDGMENTS 98
REFERENCES 99
Chapter 6. Role of Striatum in the Specific Action of the Psychostimulant and Neuroleptic Drugs 116
REFERENCES 124
Chapter 7. Learning and Memory 126
REFERENCES 144
Part II: New Drug Pathways in Depression Treatment 146
Chapter 8. Definition et Classification des Etats Depressifs 148
RESUME 148
INTRODUCTION 148
DIAGNOSTIC POSITIF DE DEPRESSION 148
DIAGNOSTIC DIFFERENTIEL AVEC LA TRISTESSE NORMALE ET AVEC LES ETATS ANXIEUX 149
DISTINCTION ENTRE DEPRESSION PRIMAIRE ET DEPRESSION SECQNDAIRE 150
SUBDIVISION DES DEPRESSIONS SECONDAIRES 151
SUBDIVISION DES DEPRESSIONS PRIMAIRES 151
CONCLUSION 154
BIBLIOGRAPHIE 154
Chapter 9. Biochemical Mechanisms of Depressive States: Evolution of Ideas 156
REFERENCES 162
Chapter 10. Therapeutic Agents Useful for Depressive States: Evolution of Ideas 166
Chapter 11. Pharmacological Spectrum of Some New Antidepressants 170
ABSTRACT 170
INTRODUCTION 170
REFERENCES 177
Chapter 12. Problems of Pharmacological Screening for Antidepressants 180
1. Antagonism of hypothermia induced by high doses of apomorphine 180
2. Antagonism of oxotremorine-induced hypothermia 181
3. Behavioral despair in rats or mice 182
REFERENCES 184
Chapter 13. Biochemical Effects of Some New Antidepressants: Putative Mechanisms of Antidepressant Effect 186
ABSTRACT 186
INTRODUCTION 186
VILOXAZINE 187
NOMIFENSINE 188
TRAZODONE 188
MIANSERIN 189
MONQAMINE NEURONES, DEPRESSION AND ANXIETY 190
SELECTIVITY OF CLINICAL EFFECTS 190
REFERENCES 191
Chapter 14. Therapeutic Effects of Some New Antidepressants 196
ABSTRACT 196
INTRODUCTION 196
SOME NEW ANTIDEPRESSANTS 197
CONCLUSION 202
REFERENCES 202
Part III: Pharmacological Interferences with Nonstriatal Dopaminergic Systems 206
Chapter 15. Dopamine Receptors in the Nucleus Accumbens 208
INTRODUCTION 208
METHODS 208
RESULTS 209
DISCUSSION 214
REFERENCES 215
Chapter 16. Regulation of Cerebral Dopamine Metabolism by Presynaptic Receptors and Lateral Inhibition 218
SUMMARY 218
INTRODUCTION 218
DOPAMINERGIC INNERVATION OF THE HIPPOCAMPUS 218
DRUG EFFECTS 219
ROLE OF PRE- AND POSTSYNAPTIC RECEPTORS 219
MAXIMAL DRUG RESPONSES AND DA METABOLISM 220
LATERAL INHIBITION 221
ACKNOWLEDGEMENTS 222
REFERENCES 222
Chapter 17. Ipsiversive-cataleptogenic Neurons of Nigra pars Reticulata: Out-put Pathways of Striatal Dopaminergic Responses 228
Histological changes after intranigral kainic acid 228
Neurochemical changes after intranigral kainic acid: evidence for nigro-thalamic and nigro-tectal GABA-ergic neurons 229
Behavioural effects of kainic-induced nigral lesions 230
Effect of kainic-induced nigral lesions on the behavioural responses elicited by striata! DA-receptor stimulation 231
Effect of intranigral picrotoxin on striatal responses. 232
REFERENCES 236
Chapter 18. The Modulation of Mesolimbic Dopamine Mechanisms via Serotonin and GABA 240
Serotonergic Involvement with Dopamine Function in the Nucleus Accumbens 241
GABA Involvement with Dopamine Function in the Nucleus Accumbens 246
REFERENCES 247
Chapter 19. Regulation of the Cholinergic Septal-hippocampal Pathway: Role of Dopaminergic Septal Afferents 250
INTRODUCTION 250
SEPTAL DOPAMINE CONTROL OF CHOLINERGIC HIPPOCAMPAL AFFERENTS 251
CONCLUSIONS 257
REFERENCES 257
Chapter 20. Reactivity of the Mesocortical Dopaminergic Neurones to Stress: Pharmacological Aspects 260
INTRODUCTION 260
METHODOLOGICAL CONSIDERATIONS 261
STIMULATORY EFFECT OF STRESS ON THE ACTIVITY OF THE MESOCORTICAL DOPAMINERGIC NEURONES PROJECTING TO THE FRONTAL CORTEX IN RATS AND IN MICE 261
SELECTIVE EFFECT OF STRESS ON THE MESOCORTICAL DOPAMINERGIC NEURONES 263
EFFECTS OF BENZODIAZEPINES ON THE STRESS-INDUCED ACTIVATION OF THE MESOCORTICAL DOPAMINERGIC NEURONES 265
CONCLUSIONS 267
REFERENCES 267
Chapter 21. The Behavioural Consequences of the Interaction Between Morphine, Substance P and Nonstriatal Dopamine Neurones 272
INTRODUCTION 272
ANATOMICAL INTERACTIONS BETWEEN OPIATES, SUBSTANCE P AND DOPAMINE NEURONES 272
STUDIES OF THE INTERACTION OF MORPHINE WITH THE MLC-DA NEURONES 273
THE EFFECT OF LOCAL INJECTIONS OF SUBSTANCE P INTO THE ORIGINS OF THE MLC-DA PATHWAY 276
REFERENCES 279
Index 282

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-4665-0 / 1483146650
• ISBN-13: 978-1-4831-4665-2 / 9781483146652