Toxicology of Radioactive Substances (eBook)

Volume 5

E. B. Kurlyandskaya, A. A. Letavet (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
194 Seiten
Elsevier Science (Verlag)
978-1-4831-5305-6 (ISBN)

Infos

The Toxicology of Radioactive Substances, Volume 5: Zinc-65 deals with the toxic properties of the radioisotope zinc-65 as well as its biological effects. Emphasis is placed on the role of stable zinc in the reaction of the body to the administration of zinc-65. Some of the results of laboratory studies on the toxic effects of zinc-65 on animals, primarily rabbits, are presented. This volume is comprised of 18 chapters and opens with an overview of certain aspects of the toxicology of radioactive zinc-65, followed by a discussion on the behavior of zinc-65 in the rat body. Subsequent chapters explore the distribution of zinc-65 in the body of rabbits following chronic oral administration; bioelectrical activity of the cerebral cortex in rabbits in conditions of prolonged administration of radioactive zinc; the effect of prolonged internal irradiation with G5ZnCl2 on the functional state of the rabbit heart; and aspects of hemopoiesis following chronic intake of radiozinc. Morphological changes in experimental animals following chronic exposure to radioactive zinc are also considered. This book will be of interest to chemists and toxicologists.

Inhalt

Front Cover 1
The Toxicology of Radioactive Substances 4
Copyright Page 5
Table of Contents 6
CHAPTER 1. TOXICOLOGY OF RADIOACTIVE ZINC-65 8
References 17
CHAPTER 2. BEHAVIOUR OF ZINC-65 IN THE RAT BODY 19
Summary 24
References 26
CHAPTER 3. DISTRIBUTION OF 65Zn IN THE BODY OF RABBITS AND DOSES RECEIVED BY THEM ON CHRONIC ADMINISTRATION OF 65ZnCl2 ORALLY 27
Technique of Investigation and Calculation of Dose 29
Results and Discussion 31
Summary 40
References 41
CHAPTER 4. THE EFFECT OF THE AMOUNT OF STABLE CARRIER ON THE LEVEL OF ACCUMULATION OF 65Zn FOLLOWING DAILY ORAL ADMINISTRATION OF 65ZnCl 42
Summary 46
References 46
CHAPTER 5. BIOELECTRICAL ACTIVITY OF THE CEREBRAL CORTEX IN RABBITS IN CONDITIONS OF PROLONGED ADMINISTRATION OF RADIOACTIVE ZINC 47
References 51
CHAPTER 6. THE EFFECT OF PROLONGED INTERNAL IRRADIATION OF RABBITS WITH 65ZnCl2 ON THE FUNCTIONAL STATE OF THE HEART 53
Experiments with Chronic Exposure to Radiozinc in Doses of 1 and 10 µCi/kg 54
Adrenaline tests. Technique 55
Ammonia tests. Technique 58
Experiments with Chronic Exposure to Radiozinc with a Dose of 0.1 µCi/kg 61
Adrenaline test 61
Ammonia test 63
Summary 64
References 64
CHAPTER 7. HAEMOPOIESIS FOLLOWING PROLONGED INTAKE OF RADIOACTIVE ZINC 67
Conclusions 78
Summary 80
References 81
CHAPTER 8. ASPECTS OF HAEMOPOIESIS FOLLOWING CHRONIC INTAKE OF RADIOZINC IN A DOSE OF 0.1 µCi/kg 82
Summary 90
CHAPTER 9. HAEMOPOIESIS AND MORPHOLOGICAL CHANGES IN THE ORGANS OF RABBITS FOLLOWING PROLONGED ADMINISTRATION OF 65Zn WITHOUT CARRIER 91
Summary 96
CHAPTER 10. CERTAIN CHANGES IN CARBOHYDRATE METABOLISM IN RABBITS FOLLOWING CHRONIC ADMINISTRATION OF 65Zn 97
Discussion 101
Summary 101
References 102
CHAPTER 11. CHANGE IN THE PROTEIN FRACTIONS OF RABBIT SERUM ON CHRONIC ADMINISTRATION OF 65Zn 103
Discussion 109
Summary 111
References 111
CHAPTER 12. THE EFFECT OF IMMUNIZATION ON THE RATIO OF RABBIT SERUM PROTEIN FRACTIONS FOLLOWING CHRONIC ADMINISTRATION OF 65Zn 113
Discussion 119
Summary 120
References 121
CHAPTER 13. PHAGOCYTIC REACTION OF RABBIT NEUTROPHILS FOLLOWING CHRONIC EXPOSURE TO RADIOACTIVE ZINC 122
Summary 125
References 125
CHAPTER 14. CHANGE IN THE COMPLEMENT LEVEL IN RABBITS AFTER PROLONGED ADMINISTRATION OF RADIOZINC (65Zn) 126
Summary 130
References 130
CHAPTER 15. THE EFFECT OF PROLONGED ADMINISTRATION OF RADIOZINC (65Zn) ON THE ANTIGENIC STRUCTURE OF RABBIT TISSUES 131
Summary 142
References 143
CHAPTER 16. THE EFFECT OF CHRONIC EXPOSURE TO RADIOACTIVE ZINC (65Zn) ON ANTIBODY FORMATION 145
Summary 153
References 153
CHAPTER 17. THE EFFECT OF THE SERUM OF RABBITS CHRONICALLY BURDENED WITH RADIOZINC (65Zn) ON TISSUE CULTURES 156
Summary 165
References 165
CHAPTER 18. MORPHOLOGICAL CHANGES IN EXPERIMENTAL ANIMALS FOLLOWING CHRONIC EXPOSURE TO RADIOACTIVE ZINC (65Zn) 167
Summary 183
References 183
INDEX 186

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-5305-3 / 1483153053
• ISBN-13: 978-1-4831-5305-6 / 9781483153056