Negative Co-Receptors and Ligands
Seiten
2013
|
2011
Springer Berlin (Verlag)
978-3-642-26777-2 (ISBN)
Springer Berlin (Verlag)
978-3-642-26777-2 (ISBN)
For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes these molecules' functions and mechanisms.
Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.
Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules.
Preface.- TIM-3 and its regulatory role in immune responses.- The role of PD-1 in regulating T cell immunity.- The role of IL-10 in regulating immunity to persistent viral infections. -Inhibitory Ly49 receptors on mouse Natural Killer cells.-Immunoregulatory roles for Fc receptor-like molecules.- Fcgamma Rs in health and disease.- TGF-beta function in immune suppression.- Subject index
| Erscheint lt. Verlag | 29.5.2013 |
|---|---|
| Reihe/Serie | Current Topics in Microbiology and Immunology |
| Zusatzinfo | VIII, 152 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 254 g |
| Themenwelt | Studium ► Querschnittsbereiche ► Infektiologie / Immunologie |
| Schlagworte | adaptive immune responses • Autoimmune diseases • chronic inflammatory diseases • Fc receptor-like molecules • Fc-receptors for IgG • Foxp3 induction • IL-10 • iTregs • Ly49 receptors • T cell immunoglobulin mucin-3 • viral persistence |
| ISBN-10 | 3-642-26777-7 / 3642267777 |
| ISBN-13 | 978-3-642-26777-2 / 9783642267772 |
| Zustand | Neuware |
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