Muscle Aging, Inclusion-Body Myositis and Myopathies (eBook)

Valerie Askanas, W. King Engel (Herausgeber)

eBook Download: PDF

2011 | 1. Auflage
264 Seiten
John Wiley & Sons (Verlag)
978-1-4443-9828-1 (ISBN)

Infos

Muscle weakness with ageing is almost inevitable, generally
beginning to manifest beyond the age of 40, and is usually
unstoppable. It can lead to reduced mobility, increased risk of
falling, injury, and even death. But "you're just
getting old" is not a sufficient diagnosis. Specific causes
of neuromuscular symptoms may explain progressive muscle weakness,
and should be investigated for potential treatment.



Muscle Ageing, Inclusion-Body Myositis and
Myopathies explores the clinical and pathological
expression of muscle weakness in aging persons. Case studies
demonstrate how physicians can more accurately diagnose weakening
elderly patients and make better management decisions.

It also explores sporadic inclusion-body myositis and hereditary
inclusion-body myopathies. The former, the most common progressive
muscle disease in the over 50s, is frequently under-diagnosed and,
with the increasing population of aged individuals, is presenting a
greater challenge. This disease of muscle has pathological
similarities with the well-known Alzheimer and Parkinson brain
diseases.

Edited and written by a leading international cast of authors,
Muscle Ageing, Inclusion-Body Myositis and Myopathies
provides a state-of-the-art guide to ageing-associated
neuromuscular disorders. It should be in the hands of all those
involved in the care of aging and muscle-weakened patients.



Titles of Related Interest

Neuromuscular Disorders

Tawil and Vennance (eds); ISBN 978-0-470-65456-9

European Handbook of Neurological Management, Vol 1,
2e

Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2

European Handbook of Neurological Management, Vol 2,
2e

Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9

Autor

Edited by Valerie Askanas, MD, PhD, Departments of Neurology and Pathology, University of Southern California, Keck School of Medicine, CA, USA W. King Engel, MD, Departments of Neurology and Pathology, University of Southern California, Keck School of Medicine, CA, USA

Inhalt

List of Contributors, vii

Preface, xi

Part 1 Muscle Aging

1 Aging of the human neuromuscular system: pathological aspects,
3

W. King Engel and Valerie Askanas

2 Aging of the human neuromuscular system: clinical
considerations, 33

W. King Engel and Valerie Askanas

3 Aging of the human neuromuscular system: patient vignettes,
55

W. King Engel, Shalini Mahajan, and Valerie Askanas

4 Mitochondrial changes in aging with particular reference to
muscle, and possible clinical consequences, 81

Salvatore DiMauro, Eric Schon, and Michio Hirano

5 Protein degradation in aging cells and mitochondria: relevance
to the neuromuscular system, 89

Jenny K. Ngo and Kelvin J. A. Davies

6 Human muscle protein metabolism in relation to exercise and
aging: potential therapeutic applications, 97

Micah J. Drummond and Blake B. Rasmussen

Part 2 Sporadic Inclusion-Body Myositis

7 Pathogenesis of sporadic inclusion-body myositis: role of
aging and muscle-fiber degeneration, and accumulation of the same
proteins as in Alzheimer and Parkinson brains, 111

Valerie Askanas, W. King Engel, and Anna Nogalska

8 Inflammatory and autoimmune features of inclusion-body
myositis, 146

Marinos C. Dalakas

9 Sporadic inclusion-body myositis: clinical symptoms, physical
findings, and diagnostic investigations, 159

Frank L. Mastaglia

10 Pathologic diagnostic criteria of sporadic inclusion-body
myositis and hereditary inclusion-body myopathy muscle biopsies,
168

Valerie Askanas and W. King Engel

Part 3 Hereditary Inclusion-Body Myopathies

11 Function and mutations of the GNE gene leading to distal
myopathy with rimmed vacuoles/hereditary inclusion-body myopathy,
animal models, and potential treatment, 177

May Christine V. Malicdan, Satoru Noguchi, and Ichizo
Nishino

12 GNE myopathy (hereditary inclusion-body myopathy/distal
myopathy with rimmed vacuoles): clinical features and epidemiology,
191

Zohar Argov, Ichizo Nishino, and Ikuya Nonaka

13 Consequences of the hereditary inclusion-body
myopathy-characteristic GNE mutations on muscle proteins in vivo
and in vitro, 199

Aldobrando Broccolini and Massimiliano Mirabella

14 Function and structure of VCP mutations leading to
inclusion-body myopathy associated with Paget disease of bone and
frontotemporal dementia, 206

Cezary Wojcik

15 Clinical spectrum of VCP myopathy, Paget disease, and
frontotemporal dementia: experimental models and potential
treatments, 219

Virginia E. Kimonis, Eric Dec, Mallikarjun Badadani, Angele
Nalbandian, Jouni Vesa, Vincent Caiozzo, Douglas Wallace, Barbara
Martin, Charles Smith, and Giles D. Watts

16 Drosophila and mouse models of hereditary myopathy caused by
mutations in VCP/p97, 230

Nisha M. Badders and J. Paul Taylor

Index, 241

Produkt-Details

• Erscheint lt. Verlag: 21.11.2011
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Orthopädie
• Schlagworte: Medical Science • Medizin • Neurologie • Neurology
• ISBN-10: 1-4443-9828-8 / 1444398288
• ISBN-13: 978-1-4443-9828-1 / 9781444398281