Glucagon

Structure, Biosynthesis & Physiological Effects

Buch | Hardcover

168 Seiten

2013
Nova Science Publishers Inc (Verlag)
978-1-62618-147-2 (ISBN)

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Since the discovery of the glucagon hormone, our knowledge of the pathophysiological changes of glucose metabolism has increased substantially. One of the first major breakthroughs in our understanding of the pathogenesis of diabetes occurred when patients with diabetic ketoacidosis were found to have very high glucagon levels. Since then, more observations confirmed hyperglucagonemia in diabetic patients. Despite the vast knowledge that we gained on glucagon, treating people with diabetes remained limited to replacing insulin, stimulating its secretion or improving its action for many years. Targeting glucagon pathway was not thought of as a valuable approach to treating diabetes until the first incretin mimetic was proved to be highly effective for not only stimulating the secretion of insulin but also for suppressing the glucagon secretion. The concept of bi-hormonal abnormality has changed the way we approach and treat diabetes. This book represents an extended and thorough review of glucagon biosynthesis and physiological effects. It also outlines the therapeutic options currently available to treat glucagon metabolic disorders. As it is intended for the whole scientific community, the material included was selected to be both clinical and scientific. It offers a unique integrative approach combining the expertise of the different specialties of endocrinology, physiology, cell biology, diabetes genetics and diabetes education.

Preface; History of Glucagon & GLP-1; Glucagon Structure, Secretion & Function; Physiological Effects of Glucagon on Cardiovascular System; The Role of Abnormal Glucagon in Type 2 Diabetes; The Role of Incretin Hormones in Glucagon Regulation & Diabetes Treatment; Glucagon Antagonists; Alpha-Cell-Mediated Beta-Like Cell Regeneration as a Putative Therapeutic Pathway For Type 1 Diabetes; Glucagon: Improving Knowledge & Education on the Antidote to Severe Hypoglycemia; Index.

Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	410 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
ISBN-10	1-62618-147-0 / 1626181470
ISBN-13	978-1-62618-147-2 / 9781626181472
Zustand	Neuware