Peripheral Receptor Targets for Analgesia (eBook)

Novel Approaches to Pain Management

Brian E. Cairns (Autor)

eBook Download: PDF

2009 | 1. Auflage
528 Seiten
John Wiley & Sons (Verlag)
978-0-470-52221-9 (ISBN)

Infos

A unique reference on peripheral pain receptor mechanisms

While considerable advances have been made on pharmacotherapies
for many chronic disease states, options available to treat chronic
pain have remained relatively unchanged for decades. However,
utilizing the receptors involved in peripheral pain transduction
mechanisms offers a significant opportunity to create novel
therapies for pain.

A comprehensive review of peripheral pain mechanisms,
Peripheral Receptor Targets for Analgesia: Novel Approaches to
Pain Management provides a unique resource that brings together
a body of knowledge that was previously widely dispersed. As such,
it gives readers a framework for further basic and clinical studies
on potential receptor targets, as well as the development of
improved topical analgesics.

Coverage includes:

* The latest discoveries by leading researchers relating to the
function of various ion channels and receptors in the peripheral
nervous system

* Novel delivery techniques

* An appendix listing currently available topical analgesic
medications

* A Foreword by Professor Lars Arendt-Nielsen of the Center for
Sensory-Motor Interaction (SMI) at Aalborg University

An unmatched resource for improving drug therapies and making
pain management more efficient, Peripheral Receptor Targets for
Analgesia supplies pharmaceutical scientists, pharmacologists,
neuroscientists, and graduate and upper-level undergraduate
students with a comprehensive, up-to-date reference.

Autor

Brian Cairns is Canada Research Chair in Neuropharmacology and an Associate Professor in the Faculty of Pharmaceutical Sciences at the University of British Columbia. The author of book chapters (including in Wiley's Handbook of Pharmaceutical Biotechnology) and more than fifty journal articles, Dr. Cairns also teaches undergraduate and graduate students about pain research and treatment, and contributes to the activities of several well-known pain research societies.

Inhalt

FOREWORD by Lars Arendt-Nielsen.

PREFACE.

CONTRIBUTORS.

PART I PERIPHERAL MECHANISM IN CLINICAL PAIN
CONDITIONS.

1. Role of Peripheral Mechanisms in Craniofacial Pain Conditions
(Barry J. Sessle).

2. Role of Peripheral Mechanisms in Spinal Pain Conditions
(Brian E. Cairns and Pradit Prateepavanich).

PART II SPECIFIC RECEPTOR TARGETS FOR PERIPHERAL
ANALGESICS.

3. Voltage-Gated Sodium Channels in Peripheral Nociceptive
Neurons as Targets For the Treatment of Pain (Theodore R.
Cummins).

4. Potassium Channels (Daisuke Nishizawa1, Toru Kobayashi,
and Kazutaka Ikeda).

5. Voltage-Gated Calcium Channels as Targets for the Treatment
of Chronic Pain (Joe McGivern).

6. Adenosine Receptors (Jana Sawynok).

7. Acid-Sensing Ion Channels and Pain (Roxanne Y. Walder,
Christopher J. Benson and Kathleen A. Sluka).

8. Vanilloid (TRPV1) and Other Transient Receptor Potential
Channels (Marcello Trevisani and Arpad Szallasi).

9. Glutamate Receptors (Brian E. Cairns).

10. Serotonin Receptors (Malin Ernberg).

11. Adrenergic Receptors (Antti Pertovaara).

12. Cholinergic Receptors and Botulinum Toxin (Parisa
Gazerani).

13. Cannabinoids and Pain Control in the Periphery (Jason J.
McDougall).

14. Opioid Receptors (Claudia Herrera Tambeli, Luana Fischer
and Carlos Amilcar Parada).

15. Calcitonin Gene-Related Peptide and Substance P
(Ranjinidevi Ambalavanar and Dean Dessem).

16. Role of Somatostatin and Somatostatin Receptors in Pain
(Ujendra Kumar).

17. Cytokines (Tumor Necrosis Factor, Interleukins) and
Prostaglandins (Per Alstergren).

18. Neurotrophic Factors and Pain (Peter Svensson).

PART III DELIVERY SYSTEMS.

19. Topical and Systemic Drug Delivery Systems Targeted Drug
Therapy (Urs Hafeli and Amit Kale).

20. Gene Therapy for Pain (Marina Mata and David J.
Fink).

21. Topical Analgesics (Akhlaq Waheed Hakim and Brian E.
Cairns).

Index.

Produkt-Details

• Erscheint lt. Verlag: 3.9.2009
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Schmerztherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • Neuroscience • Neurowissenschaften • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Schmerzmanagement • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 0-470-52221-6 / 0470522216
• ISBN-13: 978-0-470-52221-9 / 9780470522219