Strategies for Organic Drug Synthesis and Design (eBook)
700 Seiten
John Wiley & Sons (Verlag)
978-0-470-39959-0 (ISBN)
and synthesize pharmaceutically active agents. Significant updates
over the last 10 years since the publication of the 1st edition
include synthesis of enantiomerically pure isomers, novel chemical
methodologies, and new pharmaceutical agents targeted at novel
biological endpoints. Written by an experienced successful author,
this book meets the needs of a growing community of researchers in
pharmaceutical R &D, as well as medical professionals, by
providing a useful guide for designing and synthesizing
pharmaceutical agents. Additionally, it is a useful text for
medicinal chemistry students.
Daniel Lednicer, PhD, is the acclaimed author of several books on drug synthesis and discovery. His career has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. He has also served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute.
Preface
1. PROSTAGLANDINS, PEPTIDOMIMETIC COMPOUNDS, AND
RETINOIDS.
1.1 Prostaglandnis.
1.2 Peptidonimetic Compounds.
1.3 Retinoids.
1.4 A Miscellaneous Drug.
References.
2. DRUG BASED ON A SUBSTITUTED BENZENE RING
2.1 Arylethanolamines.
2.2 Aryloxypropanolamines.
2.3 Arylsulfonic Acid Derivatives.
2.4 Arylacetic and Arylpropionic Acids.
3. INDENES, NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC
COMPOUNDS
3.1 Indenes.
3.2 Naphthalenes.
3.3 Partly Reduced Naphthalenes.
3.4 Tricyclic Compounds.
References.
4. STEROIDS; PART 1: ESTRANES, GONANES, AND
ANDROSTANES
4.1 Introduction.
4.2 Steroid Starting Materials.
4.3 Estranes.
4.4 Gonanes, the 19-nor Steroids.
4.5 Androstanes.
References.
5. STEROIDS; PART 2: COMPOUNDS RELATED TO PROGESTERONE,
CORTISONE, AND CHOLESTEROL.
5.1 Introduction.
5.2 Progestins.
5.3 Corticosteroids.
5.4 Compounds Derived from Cholesterol.
References.
6. NONSTEROIDAL SEX HORMONES AND THEIR ANTAGONISTS
6.1 Introduction.
6.2 Estrogens.
References.
7. OPIOID ANAlGESICS
7.1 Introduction
7.2 Drugs Derived from Morphine.
7.3 Compounds Prepared from Thebaine.
7.4 Morphinans.
7.5 Benzomorphans.
7.6 Analgesics Based on Nonfused Piperidines.
References.
8. DRUGS BASED ON FIVE-MEMBERED HETEROCYCLES
8.1 Introduction.
8.2 Rings that Contain One Heteroatom.
8.3 Rings that Contain Two Heteroatoms.
8.4 Rings that Contains Three or More Heteroatoms.
References.
9. DRUGS BASED ON SIX-MEMBERED HETEROCYCLES.
9.1 Rings that Contain One Heteroatom.
9.2 Rings that Contain Two Heteroatoms.
9.3 Rings Containing Three Heteroatoms: The Triazines.
References.
10. FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE
RING.
10.1 Compounds that Contain One Heteroatom.
10.2 Compounds that Contain Two Heteroatoms.
10.3 Compounds that Contain Three Heteroatoms.
References.
11. SIX-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING
11.1 Compounds that Contain One Heteroatom.
11.2 Compounds that Contain Two Heteroatoms.
11.3 Compounds that Contain Three Heteroatoms.
References.
12. SEVEN-MEMBERED HETEROCYCLIC FUSED TO BENZENE.
12.1 Compounds with a Single Heterocyclic Atom.
12.2 Compounds with Two Heteroatoms.
References.
13. HETEROCYLES FUSED TO TWO AROMATIC RINGS
13.1 Compounds Containing a Single Heteroatom.
13.2 Compounds Containing Two Heteroatoms.
13.3 Pyridine-Based Fused Tricyclic Compounds.
References.
14. BETA LACTAM ANTIBIOTICS
14.1 Penicillins.
14.2 Cephalosporins.
14.3 Monobactams.
References.
15. HETEROCYCLES FUSED TO OTHER HETEROCYCLIC RINGS.
15.1 Two Fused Five-Membered Rings.
15.2 Five-Membered Heterocycles Fused to Six-Membered Rings.
15.3 Two Fused Six-Membered Rings.
15.4 Heterodiazepines.
15.5 Heterocyclic Compounds with Three or More Rings.
References.
Subject Index.
Reaction Index.
Cross Index of Biological Activities.
?In this book, Lednicer presents a detailed discussion of
strategies toward the synthesis of pharmaceutical compounds. . .
The strength of the book is the wealth of data collected in one
relatively short tone?.
Erscheint lt. Verlag | 26.3.2009 |
---|---|
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
Naturwissenschaften ► Chemie ► Organische Chemie | |
Technik | |
Schlagworte | Arzneimittelentwicklung • Chemie • Chemische Synthese • Chemistry • Drug Discovery & Development • Medical Science • Medizin • Methods - Synthesis & Techniques • Organische Chemie / Methoden, Synthesen, Verfahren • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung u. -entwicklung |
ISBN-10 | 0-470-39959-7 / 0470399597 |
ISBN-13 | 978-0-470-39959-0 / 9780470399590 |
Haben Sie eine Frage zum Produkt? |
Größe: 16,0 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich