Autoimmunity

Andrzej Górski, Hubert Krotkiewski, Michal Zimecki (Herausgeber)

Buch | Softcover

207 Seiten

2012
Springer (Verlag)
978-94-010-3877-5 (ISBN)

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The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner- gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis- eases and encompasses the actions of autoantibodies, autoantigeu-autoanti- body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim- mune disorders. The first six articles are generally concerned with the mech- anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis- eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys- tem, leading to a redirection of the immune response, would be therapeuti- cally beneficial.
The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim- munity, and the role of regulatory T cells. Further, an interesting phenome- non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.

The Paradigms of Causality and Treatment for Autoimmune Disease.- Uncovering the Differences between T Cell Tolerance and Immunity.- The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: Generation, Specificity and Mode of Action.- Epitope Spreading: a Mechanism for Progression of Autoimmune Disease.- A Role for NF-?B and the Proteasome in Autoimmunity.- Complement Regulatory Proteins and Autoimmunity.- Pathogenic Immunity in Theiler’s Virus-Induced Demyelinating Disease: a Viral Model for Multiple Sclerosis.- Evidence that Fas and FasL Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis.- The Role of Cytokines in Experimental Autoimmune Encephalomyelitis.- Involvement of Apoptotic Protease Cascade for Tissue Destruction in Sjögren’s Syndrome.- Is Lack of Peripheral Tolerance Induction a Cause for Diabetes in the Non-Obese Diabetic Mouse?.- Neuro-Endocrine-Immune Axis in Human Rheumatoid Arthritis.- The Role of T Cells in Rheumatoid Arthritis.

Zusatzinfo	VII, 207 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
	Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	94-010-3877-5 / 9401038775
ISBN-13	978-94-010-3877-5 / 9789401038775
Zustand	Neuware