Aminoglycoside Antibiotics (eBook)

From Chemical Biology to Drug Discovery

Dev P. Arya (Autor)

eBook Download: PDF

2007 | 1. Auflage
336 Seiten
John Wiley & Sons (Verlag)
978-0-470-14966-9 (ISBN)

Infos

Advances that open new avenues in developing aminoglycoside
antibiotics

During the last twenty years, there have been numerous advances in
the understanding of the chemistry, biochemistry, and recognition
of aminoglycosides. This has led to the development of novel
antibiotics and opened up new therapeutic targets for intervention.
This is the first book to provide a complete overview of recent
advances in the field and explore their tremendous potential for
drug discovery and rational drug design. With chapters written by
one or more leading experts in their specialty areas, the book
addresses the chemistry, biology, and toxicology of
aminoglycosides.

Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery
is a great resource for academic and industrial researchers in drug
design and mechanism studies and for researchers studying
antibiotic resistance, antibiotic design and synthesis, and the
discovery of novel pharmaceuticals. It is also a valuable reference
for graduate students in pharmacy, pharmaceutical science,
biophysics, medicinal chemistry, and chemical biology.

Autor

DEV P. ARYA is an Associate Professor of Chemistry and Director of the Laboratory of Medicinal Chemistry at Clemson University. He is a member of the ACS, and currently serves as the Program Chair of the Division of Carbohydrate Chemistry. His research interests lie in the development of nucleic acid targeted drugs.

Inhalt

Preface vii

Contributors ix

1. In the Beginning There Was Streptomycin 1
Julian Davies

2. The Biochemistry and Genetics of Aminoglycoside Producers 15
Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier

3. Mechanisms of Aminoglycoside Antibiotic Resistance 119
Tushar Shakya and Gerard D. Wright

4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics 141
Jinhua Wang and Cheng-Wei Tom Chang

5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181
R. Andrew Marshall and Joseph D. Puglisi

6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding a Sites Free and Complexed with Aminoglycosides 209
Jiro Kondo and Eric Westhof

7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225
Dale Kling, Christine Chow, and Shahriar Mobashery

8. Metalloaminoglycosides: Chemistry and Biological Relevance 235
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan

9. Adverse Effects of Aminoglycoside Therapy 255
Andra E. Talaska and Jochen Schacht

10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267
Lev Elson-Schwab and Yitzhak Tor

11. Novel Targets for Aminoglycosides 289
Dev P. Arya, Nicholas Shaw, and Hongjuan Xi

Index 315

Rezensionen

"This is a 'must-have' text for anyone involved in AGA teaching or
research. No better comprehensive treatise exists..."
(Journal of Medicinal Chemistry, October 18, 2007)



"There is little doubt that this volume will be a tremendous
resource for any investigator interested in the biochemistry of
aminoglycosides." (Journal of the American Chemical Society,
September 26, 2007)

Produkt-Details

• Erscheint lt. Verlag: 17.9.2007
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley series in drug discovery and development
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Wirkstoffforschung u. -entwicklung • Zell- u. Molekularbiologie
• ISBN-10: 0-470-14966-3 / 0470149663
• ISBN-13: 978-0-470-14966-9 / 9780470149669