Drug Repositioning (eBook)

Bringing New Life to Shelved Assets and Existing Drugs

Michael J. Barratt, Donald E. Frail (Autoren)

eBook Download: EPUB

2012 | 1. Auflage
498 Seiten
Wiley (Verlag)
978-1-118-27439-2 (ISBN)

Infos

The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

Autor

Michael Barratt is an independent consultant and previously?Senior Director and Technology Platform Leader at Pfizer's Global Indications Discovery Research Unit. He has?over 15?years of experience in preclinical drug discovery research and leadership. Donald Frail is an independent consultant and previously?Vice President of Pfizer Global Research and Development and Head of Pfizer's Global Indications Discovery Research Unit. He has over 20 years of industrial research and management experience in preclinical drug discovery and early clinical research.

Inhalt

About the Editors xv

Acknowledgments xvii

Contributors xix

Introduction 1

Michael J. Barratt and Donald E. Frail

References 5

Part I. Drug Repositioning: Business Case, Strategies, and
Operational Consideration 7

1. Drug Repositioning: The Business Case and Current Strategies
to Repurpose Shelved Candidates and Marketed Drugs 9

John Arrowsmith and Richard Harrison

2. Opportunities and Challenges Associated with Developing
Additional Indication for Clinical Development Candidates and
Marketed Drugs 33

Donald E. Frail and Michael J. Barratt

3. Clinical and Operational Considerations in Repositioning
Marketed Drugs and Drug Candidates 53

Damian O'Connell, David J. Sequeira, and Maria L.
Miller

4. Regulatory Considerations and Strategies for Drug
Repositioning 65

Ken Phelps

Part II. Application of Technology Platforms to Uncover New
Indications and Repurpose Existing Drugs 89

5. Computational and Bioinformatic Strategies for Drug
Repositioning Drugs 91

Richard Mazzarella and Craig Webb

6. Mining Scientific and Clinical Databases to Identify Novel
Uses for Existing Drugs 137

Christos Andronis, Anuj Sharma, Spyros Deftereos, Vassilis
Virvilis, Ourania Konstanti, Andreas Persidis, and Aris
Persidis

7. Predicting the Polypharmacology of Drugs: Identifying New
Uses through Chemoinformatics, Structural Informatics, and
Molecular Modeling-Based Approaches 163

Li Xie, Sarah L. Kinnings, Lei Xie, and Philip E. Bourne

8. Systematic Phenotypic Screening for Novel Synergistic
Combinations: A New Paradigm for Repositioning Existing Drugs
207

Margaret S. Lee

9. Phenotypic In Vivo Screening to Identify New,
Unpredicted Indications for Existing Drugs and Drug Candidates
253

Michael S. Saporito, Christopher A. Lipinski, and Andrew G.
Reaume

10. Old Drugs Yield New Discoveries: Examples from the Prodrug ,
Chiral Switch, and Site-Selective Deuteration Strategies 291

Adam J. Morgan, Bhaumik A. Pandya, Craig E. Masse, and Scott L.
Harbeson

Part III. Academic and Nonprofit Initiatives and the Role of
Alliances in the Drug Repostioning Industry 345

11. Repurposing Drugs for Tropical Disease: Case Studies and
Open-Source Screening Initiatives 347

Curtis R. Chong

12. Drug Repositioning Efforts by Nonprofit Foundations 389

13. Business Development Strategies in the Repositioning
Industry 433

Aris Persidis and Elizabeth T. Stark

14. A Case Study in Drug Repositioning: Sosei 445

Akinori Mochizuki and Makiko Aoyama

Appendix Additional Drug Repositioning Resources and Links
457

Mark A. Mitchell and Michael J. Barratt

Index 469

Rezensionen

"Overall, this book is so complete that it is a must read
for all the players in drug repositioning, not only
researches or drug developers, but also business development
specialist, investors, venture capital firms, academia and
regulators that need a compressive description that will satisfy
novice and more experienced professionals."
(ChemMedChem, 1 March 2013)

Produkt-Details

• Erscheint lt. Verlag: 11.4.2012
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Chemie • Chemistry • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-27439-3 / 1118274393
• ISBN-13: 978-1-118-27439-2 / 9781118274392