Enzyme Immunoassays
From Concept to Product Development
Seiten
2011
|
Softcover reprint of the original 1st ed. 1996
Springer-Verlag New York Inc.
978-1-4612-8495-6 (ISBN)
Springer-Verlag New York Inc.
978-1-4612-8495-6 (ISBN)
Since the classical work of Rosalyn Yalow and Solomon Berson on the radioim- munoassay of insulin in the late 1950s, which so brilliantly opened new domains in the diagnostics sector, immunoassays have been well received as a diagnostic and research tool in several disciplines of life sciences. The economics, rapidity, sensitivity, specificity, and the easy-to-use approach of immunodiagnostic tests are widely recognized, and have had a tremendous impact on clinical, agricultural, food, veterinary, and environmental diagnostics. At present, in the clinical diag- nostic sector alone, immunoassay products command an annual worldwide mar- ket value in excess of U. S. $10 billion, which is expanding by about 10% per annum. The recent trend toward increasing demand for automation of immunoassays and stable reagents clearly shows a definitive shift to nonisotopic immunoassay systems on a large scale. Historically, enzyme immunoassays have been in a prime position for in-house applications, primarily because of the easy access to inex- pensive measuring equipment as well as to a vast body of literature on labeling techniques and applications.
The recent popularity with the general public of sev- eral over-the-counter immunoassay products based on this technology, such as glucose level kits for diabetics, cholesterol screening tests, and pregnancy detec- tion test kits, is quite evident.
The recent popularity with the general public of sev- eral over-the-counter immunoassay products based on this technology, such as glucose level kits for diabetics, cholesterol screening tests, and pregnancy detec- tion test kits, is quite evident.
I: Basic Considerations (Concepts).- 1 Introduction.- 2 Antibodies: Biochemistry, Structure, and Function.- 3 Antigen-Antibody Reactions.- 4 Conjugation Techniques.- 5 Antibody Production.- 6 Enzymes and Signal Amplification Systems.- 7 Separation and Solid-Phase Systems.- II: Product Development.- 8 Immunoassay Classification and Commercial Technologies.- 9 Assay Development, Evaluation, and Validation.- 10 Reagent Formulations and Shelf Life Evaluation.- 11 Data Analysis.- 12 Documentation, Registration, and Diagnostics Start-Ups.
| Zusatzinfo | XIV, 464 p. |
|---|---|
| Verlagsort | New York, NY |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Studium ► Querschnittsbereiche ► Infektiologie / Immunologie |
| Naturwissenschaften ► Biologie ► Botanik | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| Technik ► Lebensmitteltechnologie | |
| ISBN-10 | 1-4612-8495-3 / 1461284953 |
| ISBN-13 | 978-1-4612-8495-6 / 9781461284956 |
| Zustand | Neuware |
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