Hereditary Retinopathies
Progress in Development of Genetic and Molecular Therapies
Seiten
2012
|
2012 ed.
Springer-Verlag New York Inc.
978-1-4614-4498-5 (ISBN)
Springer-Verlag New York Inc.
978-1-4614-4498-5 (ISBN)
The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.
Preface.- Introduction.- Gene-based Medicines directly targeting genetic defects and molecular pathologies common to multiple forms of disease.- Molecular Medicines.
| Erscheint lt. Verlag | 4.8.2012 |
|---|---|
| Reihe/Serie | SpringerBriefs in Genetics |
| Zusatzinfo | 5 Illustrations, color; 3 Illustrations, black and white; VII, 46 p. 8 illus., 5 illus. in color. |
| Verlagsort | New York, NY |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Augenheilkunde |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| ISBN-10 | 1-4614-4498-5 / 1461444985 |
| ISBN-13 | 978-1-4614-4498-5 / 9781461444985 |
| Zustand | Neuware |
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