Diagnostic, Prognostic and Therapeutic Value of Gene Signatures (eBook)
XI, 182 Seiten
Humana Press (Verlag)
978-1-61779-358-5 (ISBN)
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.
Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.
Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.
Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.
PrefaceChapter 1 Gene signatures and soft tissue sarcomas: status of art and perspectivesBruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe ToniniChapter 2 Heterogeneity of breast cancer: gene signatures and beyondGaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. MartensChapter 3 Gene signatures in CRC and liver metastasisDaniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio RussoChapter 4 Gene signatures in Gastrointestinal Stomal Tumors (GIST)Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybyl, and Maria Debiec-RychterChapter 5 Pancreatic Cancer GeneticsJuan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson DusettiChapter 6 Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancerRafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia WeiChapter 7 Gene signatures in Gastric CancerLaura Ottini, Mario Falchetti, and Gabriella NesiChapter 8 Gene signatures in Colorectal Cancer Alessandro Lugli and Inti ZlobecChapter 9 The role of epigenetics in cancer: from molecular function to high-throughput assaysAleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore SpicugliaChapter 10 Primary Epithelial Ovarian Neoplasms: New concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studiesBernard Czernobilsky, Leonor Leider-Trejo, and Antonio RussoChapter 11 Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patternsUmberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone
| Erscheint lt. Verlag | 3.11.2011 |
|---|---|
| Reihe/Serie | Current Clinical Pathology | Current Clinical Pathology |
| Zusatzinfo | XI, 182 p. 28 illus., 24 illus. in color. |
| Verlagsort | Totowa |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| ISBN-10 | 1-61779-358-2 / 1617793582 |
| ISBN-13 | 978-1-61779-358-5 / 9781617793585 |
| Haben Sie eine Frage zum Produkt? |
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