Biochemistry and Molecular Biology of Antimicrobial Drug Action (eBook)

Trevor J. Franklin, George Alan Snow (Autoren)

eBook Download: PDF

2006 | 6th ed. 2005
X, 182 Seiten
Springer US (Verlag)
978-0-387-27566-6 (ISBN)

Infos

Preface to the sixth edition x 1 THE DEVELOPMENT OF ANTIMICROBIAL AGENTS, PAST, PRESENT AND FUTURE 1 1. 1 The social and economic importance of antimicrobial agents 1 1. 2 All outhne of the historical development of antimicrobial agents 2 1. 3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds 9 1. 4 Uncovering the molecular basis of antimicrobial action iO 1. 5 Current trends in the discovery of antimicrobial drugs 14 1. 6. Scope and layout of the book 15 2 VULNERABLE SHIELDS—THE CELL WALLS OF BACTERIA AND FUNGI 17 2. 1 Functions of the ceU wall 17 2. 2. Structure of the bacterial wall 17 2. 3 Structure and biosynthesis of peptidoglycan 22 2. 4 Antibiotics that inhibit peptidoglycan biosynthesis 29 2. 5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria 39 2. 6 The fungal cell wall as a target for antifungal drugs 41 3 ANTIMICROBIAL AGENTS AND CELL MEMBRANES 47 3. 1 Microbe killers: antiseptics and disinfectants 47 3. 2 Cationic peptide antibiotics 52 3. 3 lonophoric antibiotics 54 3. 4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols 59 4 INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS 65 4. 1 Compounds affecting the biosynthesis and utilization of nucleotide precursors 66 4. 2 Nucleoside analogues 70 4. 3 Inhibitors of the reverse transcriptase of the human immunodeficiency virus 72 4. 4 Antibacterial inhibitors of topoisomerases 75 4.

Inhalt

The development of antimicrobial agents, past, present and future.- Vulnerable shields—the cell walls of bacteria and fungi.- Antimicrobial agents and cell membranes.- Inhibitors of nucleic acid biosynthesis.- Inhibitors of protein biosynthesis.- Antimicrobial drugs with other modes of action.- Attack and defense: drug transport across cell walls and membranes.- The genetic basis of resistance to antimicrobial drugs.- Biochemical mechanisms of resistance to antimicrobial drugs.

Produkt-Details

• Erscheint lt. Verlag: 31.10.2006
• Verlagsort: Boston
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: biochemistry • Biology • biosynthesis • Chemistry • enzymes • infectious disease • Molecular Biology
• ISBN-10: 0-387-27566-5 / 0387275665
• ISBN-13: 978-0-387-27566-6 / 9780387275666