International Review of Cell and Molecular Biology (eBook)

Kwang W. Jeon (Herausgeber)

eBook Download: PDF | EPUB

2010 | 1. Auflage
208 Seiten
Elsevier Science (Verlag)
978-0-12-381257-5 (ISBN)

Infos

International Review of Cell ,and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2008: 4.935.

* Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists

Inhalt

Front Cover 1
International Review of Cell and Molecular Biology 4
Copyright Page 5
Contents 6
Contributors 8
Chapter 1: Functional Nuclear Architecture Studied by Microscopy: Present and Future 10
1. Introduction 11
2. Historical Background 16
3. Models of Nuclear Architecture and Experimental Evidence 17
3.1. Current models 17
3.2. Experimental evidence 21
4. Perspectives: Open Questions and Possibilities to Answer Them 42
4.1. Studies of higher order chromatin arrangements 42
4.2. Nuclear topography and models of the nuclear architecture 43
4.3. Forces responsible for changes of higher order chromatin arrangements 49
4.4. Unexplored biophysical properties of nuclei 51
4.5. Summary 51
5. Quantitative Microscopic Analysis of Nuclear Architecture 53
5.1. Electron microscopy 53
5.2. Far-field fluorescence microscopy with conventional resolution 55
5.3. Far-field fluorescence microscopy with resolution beyond the Abbe limit 59
5.4. Importance of correlation microscopy for new ways to realize an old concept 70
6. Concluding Remarks 72
Acknowledgments 73
References 74
Chapter 2: Meiotic silencing in Caenorhabditis elegans 100
1. Introduction 101
2. Chromatin Regulation in the Germ Line 102
3. Repressive Mechanisms in C. elegans Meiotic Germ Line 104
3.1. Extrachromosomal transgenic arrays 106
3.2. X Chromosome silencing 108
3.3. Genome-wide analysis of germ line gene expression 109
3.4. Enrichment of H3K9me2 on male X and other unpaired chromosomes 110
3.5. Targeting mechanisms 112
3.6. Enrichment of H3K27me3 on X chromosomes 118
3.7. Regulation of germ line H3K27me3 by Polycomb Repressive Complex 2 (PRC2) system 119
3.8. Summary 121
4. Meiotic Silencing and Germ line Development in C. elegans 121
4.1. Repression of DNA insertions 123
4.2. Maintenance of genome integrity 124
4.3. Epigenetic control of embryogenesis 124
4.4. Transcriptional regulation of single X 125
4.5. Chromosome evolution 126
4.6. Summary 126
5. Mechanistic and Functional Comparison of Meiotic Silencing Phenomena in Different Species 126
5.1. Meiotic silencing in N. crassa 127
5.2. Meiotic silencing in insects 127
5.3. Meiotic silencing in mammals 128
5.4. Meiotic silencing in birds 130
5.5. Other meiotic transsensing phenomena in vertebrates 130
5.6. Summary 131
6. Noncoding RNA and Chromatin Structure 131
7. Conclusions and Future Prospects 133
7.1. Mechanism 133
7.2. Function 134
Acknowledgments 135
References 135
Chapter 3: Lipid Rafts, Caveolae, and Their Endocytosis 144
1. Introduction 145
2. The Lipid Raft 145
2.1. Origin of the concept 145
2.2. Defining raft domains 146
3. Caveolae 148
3.1. Caveolae and caveolin proteins 148
3.2. Cav1 and the regulation of caveolae formation 151
3.3. Cav1 domains outside of caveolae: Cav1 scaffolds 152
4. Raft-Dependent Endocytosis 154
4.1. Multiple rafts for multiple pathways 154
4.2. Regulation of raft-dependent endocytosis 158
4.3. Raft endocytosis and modulation of signaling cascades 160
5. Conclusion 162
References 162
Chapter 4: New Insights into the Mechanism of Fibroblast to Myofibroblast Transformation and Associated Pathologies 174
1. Introduction 175
2. Fibroblasts and Intermediates 176
3. Myofibroblasts 178
4. Fibroblast to Myofibroblast Signaling 179
4.1. Transforming growth factor-beta (TGFß) 179
4.2. TGFß cooperative proteins and independent pathways 179
5. Mononuclear Cells in Peripheral Blood That Differentiate into Myofibroblasts 181
5.1. Historical perspective 181
5.2. Neofibrosis 181
5.3. Fibrocytes 182
5.4. Other monocyte-derived progenitors of fibroblast-like cells 184
6. Myofibroblast-Associated Pathologies 185
6.1. Myofibroblasts and cardiac repair following infarction 185
6.2. Systemic sclerosis 188
7. Summary 192
References 193
Index 202
Color Plates 206

Textauszug

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Produkt-Details

• Erscheint lt. Verlag: 24.8.2010
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• ISBN-10: 0-12-381257-7 / 0123812577
• ISBN-13: 978-0-12-381257-5 / 9780123812575