Nitric Oxide (NO) and Cancer (eBook)
X, 250 Seiten
Springer New York (Verlag)
978-1-4419-1432-3 (ISBN)
Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.
Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.
Preface
Nitrous Oxide and Cancer
A role for eNOS in oncogenic Ras-driven cancer
Multifaced Role of NItric Oxide in Cancer Biology
Nitric oxide expression in cancer
S-Nitrosylation: How Cancer Cells Say NO to Cell Death
Cytotoxic and protective activity of nitric oxide cancers
Cytotoxic/protective activity of nitric oxide in cancer
Nitric oxide and life or death of human leukemia cells
Inhibition of apoptosis by endogenous nitric oxide in chronic lymphomatic leukemia
Nitric Oxide: a rate-limiting factor for metastases development
Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB-Snail-RKIP loop
Sensitizing effect of nitric oxide to cytotoxic stimuli
Nitric oxide is a promising enhancer for cancer therapy
Role of Nitric Oxide for Modulation of Cancer Therapy Resistance
Breaking Resistance: Role of Nitric Oxide in the Sensitization of Cancer Cells to Chemo-Immunotherapy
Prognostic significance of iNOS and NO in human melanoma
Prognostic significance of iNOS in heptatocellular carcinoma
Prognostic significance pf iNOS in esophageal cancer
Prognostic significance of nitrative DNA damage in infection and inflammatuion-related carcinogenesis
Nitric Oxide-releasing Melocules for Cancer Therapy and Chemoprevention
Nitric Oxide: monotherapy or sensitiser to conventional cancer treatments
Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies
S,R-3-Phenyl-4,5-dihydro-5-isoxazole Acetic Acide--Nitric Oxide GIT 27NO New Dress for Nitric Oxide Mission
Nitric Oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis
Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of HIF-1a: Potential role of Se-Methylselenocysteine (MSC),an antioxidant multi-targeted small molecule
| Erscheint lt. Verlag | 16.6.2010 |
|---|---|
| Reihe/Serie | Cancer Drug Discovery and Development | Cancer Drug Discovery and Development |
| Zusatzinfo | X, 250 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Pflege | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Schlagworte | Apoptosis • Cancer • Cancer Therapy • Cancer Treatment • Carcinogenesis • carcinoma • Cell • immunotherapy • leukemia • melanoma • Metastasis • Pain • pathogenesis • prevention • Tumor |
| ISBN-10 | 1-4419-1432-3 / 1441914323 |
| ISBN-13 | 978-1-4419-1432-3 / 9781441914323 |
| Haben Sie eine Frage zum Produkt? |
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