Brain Tumors (eBook)
XI, 393 Seiten
Humana Press (Verlag)
978-1-59259-843-4 (ISBN)
Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.
Part I: Epidemiology, Biology, Genetics, and Pathology
Epidemiology of Brain Tumors
Randa El-Zein, Melissa Bondy, and Margaret Wrensch
Molecular Genetics of Tumors of the Central Nervous System
C. David James
Molecular Pathology of Nervous System Tumors
Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, and David N. Louis
Genetic Modeling of Glioma Formation in Mice
Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, and Eric C. Holland
Biology of Brain Metastasis
Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, and Isaiah J. Fidler
Analysis of Neural Precursor Cells in the Context of Origin of Brain Tumors, Their Treatment, and Repair of Treatment-Associated Damage
Mark Noble and Joerg Dietrich
Biology of Primitive Neuroectodermal Tumors
John R. Hill, Shoichiro Ohta, and Mark A. Israel
Part II: Mechanisms and Pathways
Molecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain Tumors
Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, and Paul van der Valk
Immune Regulation in the Brain: Lessons From Autoimmunity and Implications for Brain Tumor Therapy
Lois A. Lampson
Genetic Pathways in the Evolution of Gliomas
Hiroko Ohgaki and Paul Kleihues
DNA Damage and Repair in the Therapeutic Response of Tumors of the Central Nervous System
Henry S. Friedman, M. Eileen Dolan, and Francis Ali-Osman
Role of Urokinase-Type Plasminogen Activator Receptor in Human Glioma Invasion
Sanjeeva Mohanam and Jasti S. Rao
Regulation of Cell Cycle and Apoptosis in Human Brain Tumors
Juan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnell
Part III: Therapeutics
Systemic Chemotherapy for Metastatic Tumors of the Central Nervous System
Charles A. Conrad and W. K. Alfred Yung
Radiation Biology and Therapy of Tumors of the Central Nervous System
Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, and Dennis F. Deen
Advances in the Management of Cerebral Metastases
Fadi Hanbali and Raymond Sawaya
Immunotherapy of Central Nervous System Tumors: Contemporary Cancer Research
Amy B. Heimberger, David A. Reardon, Darell D. Bigner, and John H. Sampson
Targeting Drugs to Tumors of the Central Nervous System
Maciej S. Lesniak, James Frazier, and Henry Brem
Rational Design and Development of Targeted Brain Tumor Therapeutics
Francis Ali-Osman, Henry S. Friedman, Gamil R. Antoun, David Reardon, Darell D. Bigner, and John K. Buolamwini
Index
Erscheint lt. Verlag | 28.10.2007 |
---|---|
Reihe/Serie | Contemporary Cancer Research | Contemporary Cancer Research |
Zusatzinfo | XI, 393 p. |
Verlagsort | Totowa |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
Schlagworte | Apoptosis • classification • Histopathology • Imaging • nervous system |
ISBN-10 | 1-59259-843-9 / 1592598439 |
ISBN-13 | 978-1-59259-843-4 / 9781592598434 |
Haben Sie eine Frage zum Produkt? |
Größe: 12,0 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich