Molecular Mechanisms in Spermatogenesis (eBook)

C.Y. Cheng (Herausgeber)

eBook Download: PDF

2009 | 2008
XVII, 274 Seiten
Springer New York (Verlag)
978-0-387-09597-4 (ISBN)

Infos

In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry.

In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.

Inhalt

CONTENTS 12
1 Spermatogenesis and Cycle of the Seminiferous Epithelium 17
2 Testicular Development and Spermatogenesis: 32
3 Estrogens and Spermatogenesis 58
4 Selenium, a Key Element in Spermatogenesis and Male Fertility 81
5 Extracellular Matrix and Its Role in Spermatogenesis 90
6 Inflammatory Networks in the Control of Spermatogenesis 108
7 Transcription Regulation in Spermatogenesis 131
8 Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology 149
9 Antioxidant Systems and Oxidative Stress in the Testes 170
10 Nitric Oxide and Cyclic Nucleotides: 188
11 The Sertoli Cell Cytoskeleton 202
12 Blood- Testis Barrier, Junctional and Transport Proteins and Spermatogenesis 228
13 Cross- Talk between Tight and Anchoring Junctions— Lesson from the Testis 250
14 The Role of the Leydig Cell in Spermatogenic Function 271
Index 286

Produkt-Details

• Erscheint lt. Verlag: 24.10.2009
• Zusatzinfo: XVII, 274 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Schlagworte: Cell Biology • Development • Dynamics • Regulation • tissue
• ISBN-10: 0-387-09597-7 / 0387095977
• ISBN-13: 978-0-387-09597-4 / 9780387095974