Genomic Imprinting (eBook)

Jon F. Wilkins (Herausgeber)

eBook Download: PDF

2009 | 2008
XVIII, 126 Seiten
Springer New York (Verlag)
978-0-387-77576-0 (ISBN)

Infos

The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field. Rather, the book covers more recent advances, drawing attention to the emerging subtleties and complexities associated with imprinted genes. Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father.

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Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father. This difference in expression strategy correlates with differences in the epigenetic state of the two alleles. These epigenetic differences include DNA methylation at CpG dinucleotides, as well as modifications on the histones associated with the locus. In the simplest possible cases, the promoter region of the imprinted gene is methylated during oogenesis, but not spermatogenesis (or vice versa). This methylation (and its accompanying histone modifications) results in inactivation of the modified allele. Of course, most imprinted genes do not fall into this simplest case. The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field (which would necessarily span multiple books). Rather, the book covers on some ofthe more recent advances, with the goal of drawing attention to some of the emerging subtleties and complexities associated with imprinted genes.

Inhalt

PREFACE 8
PARTICIPANTS 12
CONTENTS 14
1 DNA Methylation Reprogramming in the Germ Line 17
2 Control of Imprinting at the Gnas Cluster 32
3 The GNAS Locus and Pseudohypoparathyroidism 43
4 Imprinted Genes, Postnatal Adaptations and Enduring Effects on Energy Homeostasis 57
5 What Are Imprinted Genes Doing in the Brain? 78
6 Genomic Imprinting and Human Psychology: Cognition, Behavior and Pathology 87
7 Genomic Imprinting in Plants 105
8 Imprinted Genes and Human Disease 117
9 Evolutionary Theories of Imprinting— Enough Already! 132
Index 139

Produkt-Details

• Erscheint lt. Verlag: 1.10.2009
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Zusatzinfo: XVIII, 126 p. 17 illus., 1 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Schlagworte: Allele • DNA • genes • Promoter • transcription
• ISBN-10: 0-387-77576-5 / 0387775765
• ISBN-13: 978-0-387-77576-0 / 9780387775760