Early Brain Injury or Cerebral Vasospasm (eBook)

Vol 1: Pathophysiology

Hua Feng, Ying Mao, John H. Zhang (Herausgeber)

eBook Download: PDF

2010 | 2011
XII, 256 Seiten
Springer Wien (Verlag)
978-3-7091-0353-1 (ISBN)

Infos

More than 40 articles provide an extensive coverage of clinical and basic science advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries. Early brain injury, the new frontier of subarachnoid hemorrhage research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hemorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.

Inhalt

Preface 6
Acknowledgement 8
Contents 10
Part I: Advances in Subarachnoid Hemorrhage and Cerebral Vasospasm 14
Section I: Honored Guest & Honored Speaker Speeches
A Clinical Review of Cerebral Vasospasm and Delayed Ischaemia Following Aneurysm Rupture 16
New Regulatory, Signaling Pathways, and Sources of Nitric Oxide 18
Section II: Advances in Subarachnoid Hemorrhage Research 24
Advances in Experimental Subarachnoid Hemorrhage 25
Advances in Treatment of Cerebral Vasospasm: an Update 32
Roles of Signal Transduction Mechanisms in Cerebral Vasospasm Following Subarachnoid Hemorrhage: Overview 36
Part II: Mechanistic Studies 40
Section III: Early Brain Injury After Subarachnoid Hemorrhage 41
Hypoperfusion in the Acute Phase of Subarachnoid Hemorrhage 42
Association of APOE Polymorphism with the Change of Brain Function in the Early Stage of Aneurysmal Subarachnoid Hemorrhage 46
Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage 50
Early Micro Vascular Changes After Subarachnoid Hemorrhage 56
Immunological Response in Early Brain Injury After SAH 63
Mechanisms of Early Brain Injury After SAH: Matrixmetalloproteinase 9 68
Tyrosine Phosphatase Inhibition Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats 71
Protection of Minocycline on Early Brain Injury After Subarachnoid Hemorrhage in Rats 75
Role of Osteopontin in Early Brain Injury After Subarachnoid Hemorrhage in Rats 79
Matrix Metalloproteinase 9 Inhibition Reduces Early Brain Injury in Cortex After Subarachnoid Hemorrhage 84
Section IV: Nitric Oxide & Cortical Spreading Depolarization After Subarachnoid Hemorrhage
Nitric Oxide Synthase Inhibitors and Cerebral Vasospasm 89
The Role of Nitric Oxide Donors in Treating Cerebral Vasospasm After Subarachnoid Hemorrhage 94
Nitric Oxide in Early Brain Injury After Subarachnoid Hemorrhage 99
Nitric Oxide Related Pathophysiological Changes Following Subarachnoid Haemorrhage 104
Endothelin-1(1–31) Induces Spreading Depolarization in Rats 109
The Gamut of Blood Flow Responses Coupled to Spreading Depolarization in Rat and Human Brain: from Hyperemia to Prolonged Ischemia 116
Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations 122
Section V: Pathophysiology of Cerebral Vasospasm 128
Mitogen-Activated Protein Kinases in Cerebral Vasospasm After Subarachnoid Hemorrhage: A Review 129
Association of Apolipoprotein E Polymorphisms with Cerebral Vasospasm After Spontaneous Subarachnoid Hemorrhage 136
Impact of Subarachnoid Hemorrhage on Local and Global Calcium Signaling in Cerebral Artery Myocytes 140
Enhanced Angiogenesis and Astrocyte Activation by Ecdysterone Treatment in a Focal Cerebral Ischemia Rat Model 146
Bilirubin Oxidation Products Seen Post Subarachnoid Hemorrhage Have Greater Effects on Aged Rat Brain Compared to Young 151
Preliminary Results of an ICP-Controlled Subarachnoid Hemorrhage Rabbit Model for the Study of Delayed Cerebral Vasospasm 157
PKGIa Inhibits the Proliferation of Cerebral Arterial Smooth Muscle Cell Induced by Oxyhemoglobin After Subarachnoid Hemorrhage 160
Characteristics of In Vivo Animal Models of Delayed Cerebral Vasospasm 165
Endothelin Related Pathophysiology in Cerebral Vasospasm: What Happens to the Cerebral Vessels? 168
Expression and Role of COMT in a Rat Subarachnoid Hemorrhage Model 172
Section VI: Clinical Manifestations of Subarachnoid Hemorrhage 179
Monitoring of the Inflammatory Response After Aneurysmal Subarachnoid Haemorrhage in the Clinical Setting: Review of Literature and Report of Preliminary Clinical Experience 180
Perimesencephalic Subarachnoid Hemorrhage: Risk Factors, Clinical Presentations, and Outcome 186
The Relationship Between IL-6 in CSF and Occurrence of Vasospasm After Subarachnoid Hemorrhage 191
Non-Aneurysm Subarachnoid Hemorrhage in Young Adults 197
Cardiac Damage After Subarachnoid Hemorrhage 202
Analysis on Death-Associated Factors of Patients with Subarachnoid Hemorrhage During Hospitalization 206
Clinical Study of Changes of Cerebral Microcirculation in Cerebral Vasospasm After SAH 211
Effect of Weekend Admission on in-Hospital Mortality After Subarachnoid Hemorrhage in Chongqing China 215
The Correlation Between COMT Gene Polymorphism and Early Cerebral Vasospasm After Subarachnoid Hemorrhage 219
Fever Increased In-Hospital Mortality After Subarachnoid Hemorrhage 225
Subarachnoid Hemorrhage in Old Patients in Chongqing China 230
Author Index 234
Subject Index 236
Table of Contents for Vol. 1 242
Table of Contents for Vol. 2 246

Produkt-Details

• Erscheint lt. Verlag: 30.11.2010
• Reihe/Serie: Acta Neurochirurgica Supplement
• Reihe/Serie: Acta Neurochirurgica Supplement
• Zusatzinfo: XII, 256 p.
• Verlagsort: Vienna
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Schlagworte: cerebral vasospasm • early brain injury • pathophysiology • subarachnoid hemorrhage
• ISBN-10: 3-7091-0353-3 / 3709103533
• ISBN-13: 978-3-7091-0353-1 / 9783709103531