Sunlight, Vitamin D and Skin Cancer (eBook)

Jörg Reichrath (Herausgeber)

eBook Download: PDF

2009 | 2008
XXI, 323 Seiten
Springer New York (Verlag)
978-0-387-77574-6 (ISBN)

Infos

The goal of this volume is to offer a highly readable and comprehensive overview on our present knowledge of the positive and negative effects of UV-exposure. The book focuses on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment.

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UV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun-a serious problem-for a connection between vitamin D deficiency and various types of cancer (e. g. , colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer.

Inhalt

DEDICATION 6
PREFACE 7
ABOUT THE EDITOR... 8
PARTICIPANTS 9
CONTENTS 13
Sunlight, UV-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need? 20
Solar Ultraviolet Irradiance and Cancer Incidence and Mortality 35
Vitamin D Status and Cancer Incidence and Mortality 50
Sun Exposure and Cancer Survival in Norway: Changes in the Risk of Death with Season of Diagnosis and Latitude 62
Optimal Serum 25- Hydroxyvitamin D Levels for Multiple Health Outcomes 74
Ultraviolet Exposure Scenarios: Risks of Erythema from Recommendations on Cutaneous Vitamin D Synthesis 91
At What Time Should One Go Out in the Sun? 105
Epidemiology of Melanoma and Nonmelanoma Skin Cancer— The Role of Sunlight 108
Ultraviolet Radiation and Malignant Melanoma 123
Solar UV Exposure and Mortality from Skin Tumors 136
Health Initiatives for the Prevention of Skin Cancer 144
Sunscreens 156
UV Damage and DNA Repair in Malignant Melanoma and Nonmelanoma Skin Cancer 181
Role of Viruses in the Development of Squamous Cell Cancer and Melanoma 198
Melanoma and Nonmelanoma Skin Cancers and the Immune System 206
Solar UV- Radiation, Vitamin D and Skin Cancer Surveillance in Organ Transplant Recipients ( OTRs) 222
Histology of Melanoma and Nonmelanoma Skin Cancer 234
Cytogenetics of Melanoma and Nonmelanoma Skin Cancer 246
Molecular Biology of Basal and Squamous Cell Carcinomas 260
Molecular Biology of Malignant Melanoma 271
p53 Protein and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer 284
Apoptosis and Pathogenesis of Melanoma and Nonmelanoma Skin Cancer 302
Treatment of Melanoma and Nonmelanoma Skin Cancer 315
INDEX 338

Produkt-Details

• Erscheint lt. Verlag: 8.1.2009
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Reihe/Serie: Advances in Experimental Medicine and Biology
• Zusatzinfo: XXI, 323 p. 79 illus.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: Apoptosis • Cancer • carcinoma • Cell • cytogenetics • endocrinology • epidemiology • Genetics • Histology • melanoma • Molecular Biology • Mortality • Pathology • prevention • skin cancer
• ISBN-10: 0-387-77574-9 / 0387775749
• ISBN-13: 978-0-387-77574-6 / 9780387775746