Morphological and Cellular Aspects of Tail and Limb Regeneration in Lizards (eBook)

A Model System With Implications for Tissue Regeneration in Mammals

Lorenzo Alibardi (Autor)

eBook Download: PDF

2009 | 2010
XII, 112 Seiten
Springer Berlin (Verlag)
978-3-642-03733-7 (ISBN)

Infos

The present review covers a very neglected field in regeneration studies, namely, tissue and organ regeneration in reptiles, especially represented by the lizard model of regeneration. The term 'regeneration' is intended here as 'the ability of an adult organism to recover damaged or completely lost body parts or organs.' The process of recovery is further termed 'restitutive regeneration' when the lost part is reformed and capable of performing the complete or partial physiological activity performed by the original, lost body part. Lizards represent the only amniotes that at the same time show successful organ regeneration, in the tail, and organ failure, in the limb (Marcucci 1930a, b; Simpson 1961, 1970, 1983). This condition offers a unique opportunity to study at the same time mechanisms that in different regions of the same animal control the success or failure of regeneration. The lizard model is usually neglected in the literature despite the fact that the lizard is an amniote with a basic histological structure similar to that of mammals, and it is therefore a better model than the salamander (an a- mniote) model to investigate regeneration issues.

Inhalt

Abstract 6
Acknowledgements 7
Foreword 9
Contents 11
1: Regeneration in Reptiles and Its Position Among Vertebrates 12
Regeneration in the First Amniotes, the Reptiles 13
Significance of Tail Regeneration in Lizards: Zoological Background 18
Regeneration in Lizards: Growth Rates 25
Embryos of Lizards Fail To Regenerate Limbs and Tail 26
Histological and Histochemical Aspects of Tail Regeneration 28
Wound Healing and Blastema Formation 30
The Blastema Grows into a Cone 32
Tail Growth and Tissue Differentiation 37
Tail Scalation and Maturation 40
Histological Aspects of Limb Regeneration and Cicatrization 41
Single Tissue Regeneration in the Lizard Tail 46
Failure of Tail Regeneration and Cicatrization 58
2: Tail Regeneration: Ultrastructural and Cytological Aspects 61
Wound Healing to Blastema Formation 61
Tissue Differentiation 68
Epidermis 68
Blood Vessels, Fat, and Meninges 69
Muscles 75
Cartilage 77
Spinal Cord and Central Nerves 80
Spinal Ganglia and Peripheral Nerves 87
Growth Factors, Extracellular Matrix Proteins, and Keratins 89
Growth Factors 89
Extracellular Matrix Proteins 94
Intermediate Filament Proteins 95
3: Limb Regeneration: Ultrastructural and Cytological Aspects 99
Wound Healing and Blastema Formation 99
Scar Formation in the Limb as Compared with the Inducement of Tail Scarring 101
4: Conclusion and Perspectives: Implications for Human Regeneration 104
References 107

Produkt-Details

• Erscheint lt. Verlag: 26.11.2009
• Reihe/Serie: Advances in Anatomy, Embryology and Cell Biology
• Reihe/Serie: Advances in Anatomy, Embryology and Cell Biology
• Zusatzinfo: XII, 112 p. 28 illus., 8 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: blastema formation • cicatrization • Regeneration • tail regeneration • tissue regeneration • Vertebrate
• ISBN-10: 3-642-03733-X / 364203733X
• ISBN-13: 978-3-642-03733-7 / 9783642037337