Pathology of Malignant Mesothelioma (eBook)

Francoise Galateau-Salle (Herausgeber)

eBook Download: PDF

2010 | 2006
XII, 204 Seiten
Springer London (Verlag)
978-1-84628-012-2 (ISBN)

Infos

• Only up-to-date title in the market

• Current topic with significant media coverage

• Internationally relevant, the use of asbestos and its consequences is a global problem

• This title aids in pathological diagnosis which is very difficult

• Contributors are experts from France, UK, USA, Australia and Canada

• Plentiful, colored illustrations complete the text

• Target group exceeds pathologists: The diagnosis is evidence for medico-legal purposes, which makes the book invaluable to members of legal profession specializing in this disease

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Mesothelioma is a global problem, its incidence is rising in Europe, and it is a major health problem in the USA and other parts of the world, largely related to the previous use of asbestos products. Diagnosis, which rests on the pathology, is very difficult because of its diverse appearances and the potential for other diseases to mimic it. This monograph has been assembled by an international group of experts with a wealth of experience from France, UK, USA, Australia and Canada to aid in pathological diagnosis. In all these countries, the disease poses significant health problems. This book deals with clinical, radiological, epidemiological, molecular, and histopathological aspects of the disease. Tumors of the pleural, pericardial, peritoneal cavities as well as the ovary and tunica vaginalis are considered. Differential diagnoses of serosal-based lesions are fully discussed and the use of immunohistochemical stains is explained. Plentiful illustrations give further aid to diagnosisAn essential read for all diagnostic pathologists as well as general pathologists, who are sometimes required to diagnose the disease at biopsy or post mortem. The book will be also invaluable to members of the medical and legal professions who are involved with various aspects of this disease.

Inhalt

Preface 5
Acknowledgments 7
Table of contents 8
Contributor List 10
1 Epidemiology of Mesothelioma 12
Asbestos Exposure and Mesothelioma 14
Latency 16
Other Factors Implicated in the Induction of Mesothelioma 16
Prior Inflammatory Disorders Affecting Serosal Membranes 17
Simian Virus 40 and Mesothelioma 17
Familial Factors 17
References 17
2 Molecular Biology 22
Mechanisms of Asbestos-induced Oncogenesis 22
Molecular Targets of Asbestos-induced Reactive Oxygen and Nitrogen Species 23
Abnormal Expression of Oncogenes and Growth Factors 23
Cytogenetic Abnormalities in Malignant Mesothelioma 24
Tumor Suppressor Gene Inactivation in Mesothelioma 26
p53 Alterations in Malignant Mesothelioma 27
Simian Virus 40, a Large T Antigen in Human Mesothelioma: Its Role in Tumor Suppressor Gene Activation 28
NF2 Inactivation 29
Wilms’ Tumor-1 Susceptibility Gene 30
Conclusions 31
References 31
3 Serosal Anatomy and Anatomic Distribution of Mesothelioma 36
Anatomic Distribution of Mesothelioma 40
References 41
4 Clinical Aspects of Mesothelioma 42
Clinical Behavior 42
Radiology 43
Laboratory Findings 44
Peritoneal Mesothelioma 46
Pericardial Mesothelioma 47
Mesothelioma of the Tunica Vaginalis 47
Ovarian Mesothelioma 47
References 48
5 Management of Malignant Serosal Effusions 51
Thoracoscopy 51
References 58
6 Pathologic Diagnosis and Classification of Mesothelioma 61
Pleural Biopsy 64
Histochemical Stains 64
Immunohistochemistry 65
Electron Microscopy 65
Other Special Techniques 66
References 67
7 Macroscopic Features of Mesotheliomas 68
References 78
8 Classification and Histologic Features of Mesotheliomas 79
Epithelioid Mesothelioma 79
Immunohistochemical Features 97
Ultrastructural Features 103
Rare Forms (Variants) of Epithelioid Mesothelioma 111
Differential Diagnosis 115
Biphasic Mesothelioma 120
Sarcomatoid Mesothelioma 122
Histologic Examination 124
Immunohistochemical Features 127
Electron Microscopic Features 128
Desmoplastic Malignant Mesothelioma 129
Lymphohistiocytoid Mesothelioma 137
References 138
9 Differential Diagnosis: Mesothelial Proliferations 143
Reactive Mesothelial Proliferations 144
Epithelial-type Mesothelial Proliferations Confined to a Serosal Surface 144
Epithelioid-type Mesothelial Reactions in a Thickened Serous Membrane 147
Sequestration of Mesothelial Cells (Pseudoinvasion) 150
Inclusions of Mesothelial Cells in Lymph Nodes 151
Fibrous Pleurisy 152
Plaques 153
Peritoneal Fibrosis/Sclerosing Fibrosis 155
Fibrous Periorchitis 156
Immunohistochemical Findings in Reactive Versus Neoplastic Processes 156
References 157
10 Differential Diagnosis: Other Mesothelial Lesions 159
Adenomatoid Tumors 159
Well-differentiated Papillary Mesothelioma 161
Multicystic Mesothelioma 163
References 165
11 Differential Diagnosis:Nonmesothelial Lesions 167
Reactive Squamous Metaplasia 167
Nodular Histiocytic Mesothelial Hyperplasia 167
Endosalpingiosis and Endometriosis 169
Ectopic Decidua 169
References 170
12 Differential Diagnosis: Nonmesothelial Tumors of the Serosal Cavity: Sarcomas 171
Synovial Sarcoma 171
Epithelioid Hemangioendothelioma and Angiosarcoma 173
Leiomyosarcoma 176
Benign and Malignant Peripheral Nerve Sheath Tumor 176
Primitive Neuroectodermal Tumor 176
Desmoid Tumor 177
Desmoplastic Round Cell Tumor 178
Pleuropulmonary Blastoma 179
Inflammatory Myofibroblastic Tumor 180
References 181
13 Differential Diagnosis: Other Nonmesothelial Tumors 183
Solitary Fibrous Tumor 183
Calcifying Fibrous Pseudotumor 185
Leiomyomatosis Peritonealis Disseminata 186
Thymoma/Thymic Carcinoma 187
Melanoma 188
Serous Carcinoma 188
Lymphomas of the Serosal Cavities 188
Other Lymphomas That May Involve the Pleura 191
References 191
Appendix 194
Index 198

Produkt-Details

• Erscheint lt. Verlag: 6.5.2010
• Zusatzinfo: XII, 204 p. 169 illus., 154 illus. in color.
• Verlagsort: London
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Schlagworte: Asbestos • biopsy • carcinoma • classification • Malignant Mesothelioma • Pathology
• ISBN-10: 1-84628-012-5 / 1846280125
• ISBN-13: 978-1-84628-012-2 / 9781846280122