Hepatology (eBook)

Textbook and Atlas

Erwin Kuntz, Hans-Dieter Kuntz (Autoren)

eBook Download: PDF

2009 | 3., Third Edition 2008
XX, 937 Seiten
Springer Berlin (Verlag)
978-3-540-76839-5 (ISBN)

Infos

This comprehensive guide on hepatology contains 530 top-quality coloured figures. These include clinical and immunological findings, laparoscopic and histologic features as well as imaging procedures. This edition has been updated, revised and extended.

Inhalt

Dedication 5
Dedications 6
Authors 7
Preface to the third Edition 8
Foreword to the third edition 9
Preface to the second edition 10
Foreword to the second edition 11
Preface to the first edition 12
Foreword to the first edition 14
Abbreviations 15
Contents 20
Introduction to hepatology 21
1 History of Hepatology 21
Hepatology from ancient to modern times 22
1 Liver research in antiquity 22
2 Liver research in the Middle Ages 28
3 Liver research up to modern times 31
2 Morphology of the Liver 34
1 Embryology of the liver 35
2 General anatomy of the liver 36
3 Structure and histology of the liver 39
4 Nervous system 45
5 Hepatic lobules and acinus 45
6 Subcellular structures 48
3 Biochemistry and Functions of the Liver 53
1 Metabolic functions of the liver 54
2 Regulatory metabolic mechanisms 54
3 Bilirubin metabolism of the liver 55
4 Porphyrin metabolism of the liver 56
5 Bile acid metabolism of the liver 57
6 Amino acid and protein metabolism of the liver 60
7 Carbohydratemetabolism of the liver 62
8 Lipid metabolism of the liver 64
9 Hormone metabolism and the liver 67
10 Vitamin metabolism and the liver 69
11 Trace elements and the liver 71
12 Biotransformation and detoxification 74
13 Ammonia detoxification and bicarbonate neutralization 79
14 Alcohol uptake and degradation 82
15 Reticuloendothelial system 87
16 Radicals and antioxidants 88
17 Cellular transport processes 91
Diagnostics in Liver Diseases 95
4 Clinical findings 95
1 Elements of liver diagnostics 96
2 Clinical findings 98
3 Liver check list 110
5 Laboratory diagnostics 112
1 Four epochs of laboratory liver diagnostics 113
2 Difficulties of laboratory liver diagnostics 113
3 Prerequisites for correct laboratory findings 114
4 Selection criteria for liver tests 115
5 Assessment of hepatocellular integrity 116
6 Disorders of excretion 122
7 Disorders of synthesis capacity 126
8 Disorders of metabolism 130
9 Diagnostics of liver functions 130
10 Assessment of mesenchymal reaction 133
11 Serological diagnostics of viral hepatitis 135
12 Immunological diagnostics 140
13 Biochemical algorithmic diagnostics 144
6 Sonography 148
1 Physical principles 149
2 Special sonographic techniques 150
3 Examination of the liver 153
4 Diffuse liver diseases 155
5 Circumscribed liver diseases 158
6 Examination of the spleen 162
7 Liver biopsy and laparoscopy 166
1 Liver biopsy 167
2 Laparoscopy 174
3 New technical progress 187
4 Synopsis and recommendation 187
8 Radiological diagnostics 194
1 Computer tomography 195
2 Magnetic resonance imaging 201
3 Angiography 203
4 Cholangiography 208
9 Scintigraphic diagnostics 216
1 Principle 217
2 RES scintigraphy 217
3 Hepatobiliary sequential scintigraphy 218
4 Erythrocyte scintigraphy 220
5 Positron emission tomography 220
6 Flow diagram in suspected “ liver tumour” 221
10 Neurological and psychological diagnostics 224
1 Brain disorders in liver diseases 225
2 Diagnosis of disorders in cerebral performance 225
3 Basic psychometric programme 227
4 Synopsis 231
Symptoms and Syndromes 233
11 Hepatomegaly and splenomegaly 233
1 Hepatomegaly 234
2 Splenomegaly 236
12 Jaundice 239
1 Definition 240
2 Localization of bilirubin 240
3 Different shades of jaundice 240
4 Clinical classification of jaundice 240
5 Functional hyperbilirubinaemias 243
6 Differential diagnosis of jaundice 248
7 Therapy 249
13 Cholestasis 251
1 Definition 252
2 Pathogenesis 252
3 Morphological changes 253
4 Forms of cholestasis 254
5 Causes of cholestasis 254
6 Diagnosis 259
7 Clinical sequelae 264
8 Therapy 264
14 Portal hypertension 267
1 Definition 268
2 Pathogenesis 268
3 Forms and aetiology 269
4 Diagnosis 274
5 Sequelae of portal hypertension 277
6 Therapy 282
15 Hepatic encephalopathy 287
1 Definition 288
2 Pathogenesis 289
3 Morphological damage to the CNS 293
4 Causative and trigger factors 293
5 Clinical forms 294
6 Clinical stages 297
7 Diagnosis 299
8 Prognosis 301
9 Therapy 301
16 Oedema and ascites 309
1 Water and electrolyte balance 310
2 Definition 311
3 Pathogenesis 312
4 Aetiology of ascites 318
5 Diagnosis of ascites 319
6 Complications of ascites 324
7 Spontaneous bacterial peritonitis 324
8 Conservative therapy of ascites 326
9 Refractory ascites 332
10 Invasive therapeutic procedures 332
11 Surgical treatment 337
12 Liver transplantation 338
17 Hepatorenal syndrome 344
1 Definition 345
2 Pathogenesis 345
3 Clinical aspects 346
4 Prophylaxis and therapy 349
18 Hepatopulmonary syndrome 353
1 Definition 354
2 Epidemiology 354
3 Causes and pathogenesis 354
4 Clinical aspects 356
5 Hypertrophic osteoarthropathy 356
6 Therapy 357
7 Portopulmonary hypertension 357
19 Coagulopathy and haemorrhage 361
1 Coagulopathy 362
2 Upper gastrointestinal haemorrhage 367
3 Bleeding oesophageal varices 372
4 Lower gastrointestinal haemorrhage 386
20 Acute and chronic liver insufficiency 393
1 Definition 394
2 Systematics 394
3 Acute liver insufficiency 394
4 Chronic liver insufficiency 399
5 Therapy 401
Clinical Aspects of Liver Diseases 411
21 Clinical and morphological principles 411
1 Attempt at a systematic approach 412
2 Clinical forms of liver disease 412
3 Basic morphological processes of the liver 414
4 Hepatitis and hepatosis 425
5 Fibrosis and cirrhosis 426
6 Liver tumours 430
22 Acute viral hepatitis (A SEN) 432
1 History of acute viral hepatitis 434
2 Morphology and aetiopathogenetic range 435
3 Acute viral hepatitis A 439
4 Acute viral hepatitis B 444
5 Acute viral hepatitis C 461
6 Acute viral hepatitis D 467
7 Acute viral hepatitis E 469
8 Acute viral hepatitis NA-NE 471
9 HF virus 471
10 HG virus 471
11 GB viruses 472
12 TT virus 472
13 SEN virus 473
14 Other viruses 473
23 Acute concomitant viral hepatitis 485
1 Secondary hepatotropic viruses 486
2 Exotic hepatotropic viruses 490
24 Bacterial infections and the liver 495
1 Pathogenesis 496
2 Types of lesion 496
3 Bacterial pathogens 496
25 Parasitic infections and the liver 508
1 Protozoiases 509
2 Helminthiases 515
26 Mycotic infections and the liver 528
1 Predisposing factors 529
2 Pathogens 529
3 Diagnostics 529
4 Morphological findings 530
5 Hepatobiliary organ mycoses 530
6 Therapy 532
27 Liver abscess 534
1 Definition 535
2 Pathogenesis 535
3 Pathogens 535
4 Causes 536
5 Clinical picture and diagnosis 536
6 Localization 538
7 Complications 538
8 Therapy 538
9 Prognosis 539
28 Alcohol-induced liver damage 542
1 The “alcohol” factor 543
2 Biochemical effects of alcohol 545
3 Morphological effects of alcohol 548
4 Pathogenesis 552
5 Clinical features of alcoholic liver damage 554
6 Complications 558
7 Diagnostic alcohol markers 559
8 Prognosis 561
9 Therapy 561
29 Drug-induced liver damage 566
1 Drugs as foreign substances 567
2 Frequency 567
3 Pathogenesis 568
4 Morphological reactions 570
5 Clinical aspects 576
6 Prognosis 580
8 Hepatotoxic remedies (selection) 580
7 Therapy 580
30 Liver damage due to toxic substances 590
1 Historical review 591
2 Detoxification of toxic substances 592
3 Pathophysiology 593
4 Morphology 593
5 Toxic substances 593
6 Diagnostics 599
7 Therapeutic aspects 600
8 Industrial hepatotoxic agents 601
31 Metabolic disorders and storage diseases 604
1 Definition 606
2 Pathogenesis 606
3 Non-alcoholic fatty liver disease 606
4 Faulty nutrition 615
5 Reye’s syndrome 617
6 Acute fatty liver of pregnancy 617
7 Mauriac’s syndrome 618
8 Protein storage diseases 618
9 Amino acid storage diseases 621
10 Carbohydrate storage diseases 623
11 Lipid storage diseases 626
12 Sphingolipid storage diseases 628
13 Mucoviscidosis 631
14 Zellweger’s syndrome 631
15 Porphyrias 632
16 Wilson’s disease 639
17 Haemochromatosis 646
18 Haemosiderosis 656
32 Autoimmune hepatitis 666
1 Definition 667
2 Epidemiology 667
3 Aetiology 667
4 Pathogenesis 667
5 Classification 669
6 Morphology 671
7 Clinical aspects 672
8 Course and prognosis 673
9 Therapy 674
33 Cholangitis and cholangiodysplasia 679
1 Definition 680
2 Systematics and aetiology 680
3 Cholangitis 681
4 Primary biliary cholangitis 685
5 Primary sclerosing cholangitis 696
6 Autoimmune cholangitis 703
7 Overlap syndrome 705
8 Cholangiodysplasia 706
34 Chronic hepatitis 721
1 Historical review 722
2 Definition 722
3 Histology 722
4 Aetiology and differential diagnosis 726
5 Diagnosis 727
6 Course and prognosis 728
7 Therapy 732
35 Liver cirrhosis 747
1 Historical review 748
2 Definition 748
3 Aetiological classification 748
4 Morphological classification 749
5 Epidemiology 753
6 Aetiology 753
7 Clinical classification 755
8 Diagnosis 756
9 Prognostic classification 760
10 Differential diagnosis 761
11 Consequences and complications 761
12 Prognosis 773
13 Therapy 774
36 Benign hepatic lesions and tumours 783
1 Definition 784
2 Classification 784
3 Diagnostics 785
4 Differential diagnosis 786
5 Surgical treatment 800
37 Malignant liver tumours 805
1 Historical review 806
2 Classification 806
3 Hepatocellular carcinoma 808
4 Cholangiocellular carcinoma 823
5 Cystadenocarcinoma 826
6 Hepatoblastoma 827
7 Mesenchymal liver tumours 827
8 Neuroendocrine tumours 829
9 Malignant lymphoma 830
10 Liver metastases 830
38 Systemic diseases and the liver 846
1 Systemic haematological diseases 847
2 Systemic lymphatic diseases 849
3 Systemic rheumatic diseases 854
4 Mastocytosis 856
5 Histiocytosis X 857
39 Cardiovascular diseases and the liver 860
1 Cardiocirculatory disorders of the liver 861
2 Disorders of the hepatic veins 865
3 Disorders of the portal vein 869
4 Disorders of the hepatic arteries 873
5 Hereditary haemorrhagic telangiectasia 875
40 Treatment of liver diseases 879
1 From mythology to provable treatment 880
2 Clinical studies 881
3 Principles of liver therapy 883
4 Nutritional therapy of liver diseases 886
5 Drug therapy of liver diseases 889
6 Surgical therapy of liver diseases 906
7 Liver transplantation 911
8 Sociomedical aspects 919
Index 932

Produkt-Details

• Erscheint lt. Verlag: 11.3.2009
• Zusatzinfo: XX, 937 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Schlagworte: biopsy • Diagnostics • hepatology • Imaging • liver disease • text book
• ISBN-10: 3-540-76839-4 / 3540768394
• ISBN-13: 978-3-540-76839-5 / 9783540768395