New Frontiers in Lifestyle-Related Diseases (eBook)

Michio Imawari, Akira Miyazaki (Herausgeber)

eBook Download: PDF

2009 | 2008
XXII, 160 Seiten
Springer Japan (Verlag)
978-4-431-76428-1 (ISBN)

Infos

It is my great pleasure to publish New Frontiers in Lifestyle-Related Dis­ eases, the proceedings of the Showa University International Symposium for Life Sciences, 3rd Annual Meeting, held at Showa University on Sep­ tember 13, 2006. This symposium was supported, in part, by Grants for the Promotion of the Advancement of Education and Research in Graduate Schools and Ordinary Expenses for Private Schools from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. On behalf of Showa University, I would like to express my deepest thanks to all the authors and editors for their great contribution to the publication of this memorable book that accelerates research activity in lifestyle-related diseases. Akiyoshi Hosoyamada, M.D., Ph.D. President, Showa University Tokyo, Japan September 2007 v Preface The leading cause of death in Western countries and some developing countries is atherosclerotic cardiovascular diseases. Among them, acute myocardial infarction is the most common type of fatal disease, caused by the progression of atherosclerosis characterized by accumulation of choles­ terol in vascular walls. Development of atherosclerosis is greatly enhanced by major risk factors for cardiovascular diseases such as obesity, hyperlip­ idemia, diabetes (hyperglycemia), and hypertension. Among those, obesity frequently initiates a metabolic change that subsequently induces hyperlip­ idemia, diabetes, hypertension, and eventually atherosclerotic cardiovascu­ lar diseases. Because obesity and its related disorders largely depend on lifestyle factors such as high calorie intake and low physical activity, a series of disorders are termed lifestyle-related diseases.

Inhalt

Foreword 5
Preface 6
Contents 7
Contributors 10
Color Plates 15
Part I Regulation of Feeding and Energy Homeostasis in the Brain 19
Orphan Neuropeptides and the Regulation of Food Intake 20
Neuronal Mechanisms of Feeding Regulation by Peptides 37
Distribution and Localization of Galanin- like peptide ( GALP) in Brain 45
Functional Analysis of GALP in . Feeding Regulation 55
Regulation of Energy Homeostasis by GALP 62
Part II Lipid Metabolism and Atherosclerosis 69
Cholesterol Trafficking and Esterification With Relation to Atherosclerosis and Neurodegenerative Diseases 70
Atherogenic Lipoproteins in Type 2 Diabetes with Nephropathy 83
Remnants LDL- C HDL- C 85
Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/ p23 89
Regulation of Intracellular Lipid Storage and Adipose Differentiation- Related Protein ( ADRP) 93
Lipid droplets 94
Roles of Vasoactive Agents in Macrophage Foam Cell Formation and Atherosclerosis 101
Part III Risk Factors for Cardiovascular Diseases 109
Sleep Apnea and Metabolic and Cardiovascular Complications 110
Sleep Apnea Syndrome and Atherosclerosis 117
Significance of Small Dense Low- Density Lipoproteins in Coronary Heart Disease 125
Statin decreases IL- l and LPS- induced inflammatory cytokines production in oral epithelial cells 135
Part IV Poster Sessions 142
Onco- suppressor p53 protein prevents an Alzheimer disease mouse model, Pin1- null mouse from the increase of presenilin- 1. 143
Quantification of mouse oxidized lipoprotein by sandwich ELISA low- density 147
Regulation of sPLA2- IIA expression in cytokine-stimulated rat fibroblasts 151
Comparison Between Small Dense LDL-Cholesterol and LDL- Cholesterol to Predict Coronary Events in Stable Coronary Heart Disease 155
Acceleration of foam cell formation by leptin in human monocyte- derived macrophages 162
Key word index 166

Produkt-Details

• Erscheint lt. Verlag: 25.2.2009
• Zusatzinfo: XXII, 160 p. 33 illus., 5 illus. in color.
• Verlagsort: Tokyo
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: atherosclerosis • coronary heart disease • Diabetes • homeostasis • Lifestyle-Related Diseases • Lipid metabolism • risk factor
• ISBN-10: 4-431-76428-3 / 4431764283
• ISBN-13: 978-4-431-76428-1 / 9784431764281