Stem Cell Research and Therapeutics (eBook)

Yanhong Shi, Dennis Clegg (Herausgeber)

eBook Download: PDF

2008 | 2008
XVIII, 326 Seiten
Springer Netherland (Verlag)
978-1-4020-8502-4 (ISBN)

Infos

This book is an updated reference for one of the most exciting field of biomedical researches- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and li ver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, postdoctoral fellows, academic and industrial scientists, and clinicians. v Acknowledgements The editors would like to thank Ms. Jill Brantley, Rose Chavarin, Alina Haas, and Emily Sun for their administrative assistance and proof-reading of this book. We would also like to thank all the authors for their contributions. vii The editors wish to dedicate this book to our mentors Ron Evans, Fred Gage, and, in memory of Daniel E. Koshland, Jr. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Dennis O. Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu, and Lincoln V.

Inhalt

Preface 5
Acknowledgements 6
Contents 8
Contributors 10
Chapter 1 Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration 15
1.1 Introduction 16
1.2 Molecular, Cellular and Genetic Studies of AMD 16
1.3 The Retinal Pigment Epithelium 18
1.4 Differentiation of hESC into RPE-Like Cells 25
1.5 Future Directions 30
References 31
Chapter 2 Progenitor Cell Transplantation for Retinal Disease 39
2.1 Neural Repair 40
2.2 Retinal Repair 40
2.3 Transplantation of Neural Progenitor Cells to the Retina 42
2.4 Retinal Progenitor Cells 42
2.5 Marker Expression 43
2.6 Immunology of CNS Progenitor Cells 46
2.7 Proliferation 47
2.8 Differentiation 48
2.9 Cell Delivery 50
2.10 Gene Delivery 52
2.11 Alternate Cell Types 52
2.12 Conclusion 54
References 54
Chapter 3 Negative Regulation of Endogenous Stem Cells in Sensory Neuroepithelia: Implications for Neurotherapeutics 59
3.1 Introduction 60
3.2 Olfactory Epithelium as a Model System for Understanding Molecular Regulation of Endogenous Neural Stem Cells 60
3.3 Molecular Regulation of OE Neurogenesis In Vitro 63
3.4 Negative Regulation of Neurogenesis In Vivo and In Vitro 72
3.5 Conclusions and Future Directions 75
References 78
Chapter 4 Epigenetic Control of Neural Stem Cell Self-Renewal and Specification 83
4.1 Introduction 83
4.2 Histone Modification in Neural Stem Cells 85
4.3 DNA Methylation in Neural Stem Cells 88
4.4 Chromatin Remodeling Complexes in Neural Stem Cells 90
4.5 MicroRNA in Neural Stem Cells 91
4.6 Perspectives 93
References 93
Chapter 5 Neural Stem Cells and Neurogenic Niche in the Adult Brain 97
Chapter 6 Progressing Neural Stem Cell Lines to the Clinic 118
6.1 Introduction: Clinical Indications for Transplant Therapy 118
6.2 Early Success and Proof of Concept 120
6.3 Stem Cells as a Standardised Therapeutic Product 123
References 132
Chapter 7 Human Neural Stem Cells for Biopharmaceutical Applications 136
Chapter 8 The Analysis of MicroRNAs in Stem Cells 154
Chapter 9 Optimized Growth of Human Embryonic Stem Cells 181
Chapter 10 Potential of Stem Cells in Liver Regeneration 193
Chapter 11 Cell Transplantation Therapy for Myocardial Repair: Current Status and Future Challenges 205
Chapter 12 Surgical Stem Cell Therapy for the Treatment of Heart Failure 225
Chapter 13 Use of Combinatorial Screening to Discover Protocols That Effectively Direct the Differentiation of Stem Cells 238
Chapter 14 Adult Stem Cell Therapies for Tissue Regeneration: Ex Vivo Expansion in an Automated System 262
Chapter 15 The Hair Follicle Stem Cell as the Paradigm Multipotent Adult Stem Cell 286
Index 299
Color Plates 301

Produkt-Details

• Erscheint lt. Verlag: 15.7.2008
• Reihe/Serie: Advances in Biomedical Research
• Reihe/Serie: Advances in Biomedical Research
• Zusatzinfo: XVIII, 326 p.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: Biology • Cell • Cell Biology • Cell Therapy • Liver • Population • Regenerative medicine • RNA • Screening • Stem Cell • tissue • Transplantation
• ISBN-10: 1-4020-8502-8 / 1402085028
• ISBN-13: 978-1-4020-8502-4 / 9781402085024