Interferon: The 50th Anniversary (eBook)

Paula M. Pitha (Herausgeber)

eBook Download: PDF

2007 | 2007
VIII, 392 Seiten
Springer Berlin (Verlag)
978-3-540-71329-6 (ISBN)

Infos

A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine's most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction. Recent work with genetically modified mice seems to confirm the original idea that interferon is the first cellular defense against viral infection.

Inhalt

Preface 5
List of Contents 7
List of Contributors 9
Part I: Reflections 10
How to Chase a Red Herring and Come up with a Smallmouth Bass 11
Interferon Research BC (Before Cloning) 16
Purification and Cloning of Interferon Alpha 30
Part II: Interferons and Their Signaling Pathways 45
Type I Interferon: The Ever Unfolding Story 46
The Receptor of the Type I Interferon Family 76
IFN-. : Recent Advances in Understanding Regulationof Expression, Biological Functions, and Clinical Applications 101
Cell Type-Specific Signaling in Response to Interferon-y 122
Interferon Research: Impact on Understanding Transcriptional Control 158
Part III: Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction 167
TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War 168
Regulation of Antiviral Innate Immune Responses by RIG- I Family of RNA Helicases 194
Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids 207
Part IV: Interferon-Induced Genes 231
The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double- Stranded RNA, and Viruses 232
Part IV: Interferon-Induced Genes 250
Structure and Function of the Protein Kinase R 251
Part V: Virus Defense 291
Viral Regulation and Evasion of the Host Response 292
Pathogenic Viruses: Smart Manipulators of the Interferon System 311
Part VI: Role of Interferon in Viral Infection and Autoimmunity 331
Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator 332
Type I Interferon in Systemic Lupus Erythematosus 353
Index 381

Produkt-Details

• Erscheint lt. Verlag: 29.8.2007
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: VIII, 392 p. 35 illus., 22 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: Acquired immune system • autoimmune disease • Autoimmune diseases • autoimmunity • Cell • Cytoplasm • Diseases • Gene • gene expression • immune system • Infection • innate antiviral immune response • Interferon • Oncology • Protein • RNA • Viral Infection • Viral Replication • Virology • Virus
• ISBN-10: 3-540-71329-8 / 3540713298
• ISBN-13: 978-3-540-71329-6 / 9783540713296