Tissue Repair, Contraction and the Myofibroblast (eBook)

Christine Chaponnier, Alexis Desmoulière, Giulio Gabbiani (Herausgeber)

eBook Download: PDF

2007 | 2006
XII, 142 Seiten
Springer US (Verlag)
978-0-387-33650-3 (ISBN)

Infos

Tissue Repair, Contraction and the Myofibroblast summarizes the latest findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. Coverage shows that the myofibroblast is responsible for the development of hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma. Reviews the cell biology and pathology of the myofibroblast as well as mechanisms of fibrosis evolution in many organs and tissues.

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hirty-four years after the first description of the myofibroblast, the number of publications concerning this cell is very impressive and Tcontinuously expanding, and the work on the myofibroblast involves many laboratories throughout the world. The myofibroblast has been implicated in developmental and physiological phenomena, as well as in a variety of pathological situations, going from wound healing and fibrotic changes to asthma and cancer invasion. Many aspects of myofibroblast biology have been clarified, such as the role of TGF-P and ED-A cellular fibronectin in its differentiation and the role of a-smooth muscle actin in tension production by this cell; however several important problems concerning myofibroblast origin, ftmction and participation in pathological processes remain to be solved. The purpose of this book, as well of the Meeting "e;Tissue Repair, Contraction and the Myofibroblast"e; that took place in Nyon, near Geneva, Switzerland on November 18-20, 2004, is to put together the most recent advances in the understanding of myofibroblast biology and to present the main directions of research taking place worldwide to explore new aspects of myofibroblast physiological and pathological activities, such as: mechanisms of force generation by the myofibroblast; myofibroblast origin and diversity; interaction of the myofibroblast with other cells, normal and malignant epithelial cells in particular; and participation of the myofibroblast in the development of fibrosis in various organs. If we consider the animated and constructive discussions that took place during the Nyon Meeting, we are sure that this book will inspire new research in these fields.

Inhalt

CONTENTS 4
PREFACE 12
The Evolution of the Concept of Myofibroblast: 14
1 Cytomechanics in Connective Tissue Repair and Engineering 20
2 Scleroderma Lung Fibroblasts: Contractility and Connective Tissue Growth Factor 38
3 Functional Assessment of Fibroblast Heterogeneity by the Cell- Surface Glycoprotein Thy- 1 45
4 Tissue Repair in Asthma: The Origin of Airway Subepithelial Fibroblasts and Myofibroblasts 53
5 Experimental Models to Study the Origin and Role of Myofibroblasts in Renal Fibrosis 60
6 Epithelial to Mesenchymal Transition of Mesothehal Cells as a Mechanism Responsible for Peritoneal Membrane Failure in Peritoneal Dialysis Patients 66
7 FIZZy Alveolar Epithelial Cells Induce Myofibroblast Differentiation 81
8 Pro-Invasive Molecular Cross-Signaling between Gincer Cells and Myofibroblasts 87
9 Proangiogenic Implications of Hepatic Stellate Cell TransdiflFerentiation into Myofibroblasts Induced by Tumor Microenvironment 101
10 Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinase and Matrix Turnover and the Fate of Hepatic Stellate Cells 115
11 Innate Immune Regulation of Lung Injury and Repair 123
Index 152

Produkt-Details

• Erscheint lt. Verlag: 26.2.2007
• Reihe/Serie: Biotechnology Intelligence Unit
• Reihe/Serie: Biotechnology Intelligence Unit
• Zusatzinfo: XII, 142 p. 60 illus., 13 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• Schlagworte: Asthma • Biology • Cancer • Cell • Cell Biology • Development • Evolution • Eye • glycoprotein • Membrane • Pathology • Protein • Regulation • tissue • Tumor
• ISBN-10: 0-387-33650-8 / 0387336508
• ISBN-13: 978-0-387-33650-3 / 9780387336503